Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases
The excessive formation of reactive oxygen species (ROS) and impairment of defensive antioxidant systems leads to a condition known as oxidative stress. The main source of free radicals responsible for oxidative stress is mitochondrial respiration. The deleterious effects of ROS on cellular biomolec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13384 |
| _version_ | 1797503868110635008 |
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| author | Paweł Kowalczyk Dorota Sulejczak Patrycja Kleczkowska Iwona Bukowska-Ośko Marzena Kucia Marta Popiel Ewa Wietrak Karol Kramkowski Karol Wrzosek Katarzyna Kaczyńska |
| author_facet | Paweł Kowalczyk Dorota Sulejczak Patrycja Kleczkowska Iwona Bukowska-Ośko Marzena Kucia Marta Popiel Ewa Wietrak Karol Kramkowski Karol Wrzosek Katarzyna Kaczyńska |
| author_sort | Paweł Kowalczyk |
| collection | DOAJ |
| description | The excessive formation of reactive oxygen species (ROS) and impairment of defensive antioxidant systems leads to a condition known as oxidative stress. The main source of free radicals responsible for oxidative stress is mitochondrial respiration. The deleterious effects of ROS on cellular biomolecules, including DNA, is a well-known phenomenon that can disrupt mitochondrial function and contribute to cellular damage and death, and the subsequent development of various disease processes. In this review, we summarize the most important findings that implicated mitochondrial oxidative stress in a wide variety of pathologies from Alzheimer disease (AD) to autoimmune type 1 diabetes. This review also discusses attempts to affect oxidative stress as a therapeutic avenue. |
| first_indexed | 2024-03-10T03:56:31Z |
| format | Article |
| id | doaj.art-4e0f46505b2947a4adebcf44e43f0463 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:31Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4e0f46505b2947a4adebcf44e43f04632023-11-23T08:45:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241338410.3390/ijms222413384Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many DiseasesPaweł Kowalczyk0Dorota Sulejczak1Patrycja Kleczkowska2Iwona Bukowska-Ośko3Marzena Kucia4Marta Popiel5Ewa Wietrak6Karol Kramkowski7Karol Wrzosek8Katarzyna Kaczyńska9Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, PolandDepartment of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandAnalytical Group, Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy with Laboratory Medicine Division, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 02-091 Warsaw, PolandR&D Department Nutropharma LTD, Jedności 10A, 05-506 Lesznowola, PolandDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, PolandR&D Department Nutropharma LTD, Jedności 10A, 05-506 Lesznowola, PolandDepartment of Physical Chemistry, Medical University of Bialystok, Kilińskiego 1 Str., 15-089 Białystok, PolandDepartment of Heart Diseases, The Medical Center of Postgraduate Education, Marymoncka 99/103, 01-813 Warsaw, PolandDepartment of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandThe excessive formation of reactive oxygen species (ROS) and impairment of defensive antioxidant systems leads to a condition known as oxidative stress. The main source of free radicals responsible for oxidative stress is mitochondrial respiration. The deleterious effects of ROS on cellular biomolecules, including DNA, is a well-known phenomenon that can disrupt mitochondrial function and contribute to cellular damage and death, and the subsequent development of various disease processes. In this review, we summarize the most important findings that implicated mitochondrial oxidative stress in a wide variety of pathologies from Alzheimer disease (AD) to autoimmune type 1 diabetes. This review also discusses attempts to affect oxidative stress as a therapeutic avenue.https://www.mdpi.com/1422-0067/22/24/13384mitochondriamitochondrial diseasesoxidative stressantioxidant therapy |
| spellingShingle | Paweł Kowalczyk Dorota Sulejczak Patrycja Kleczkowska Iwona Bukowska-Ośko Marzena Kucia Marta Popiel Ewa Wietrak Karol Kramkowski Karol Wrzosek Katarzyna Kaczyńska Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases International Journal of Molecular Sciences mitochondria mitochondrial diseases oxidative stress antioxidant therapy |
| title | Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases |
| title_full | Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases |
| title_fullStr | Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases |
| title_full_unstemmed | Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases |
| title_short | Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases |
| title_sort | mitochondrial oxidative stress a causative factor and therapeutic target in many diseases |
| topic | mitochondria mitochondrial diseases oxidative stress antioxidant therapy |
| url | https://www.mdpi.com/1422-0067/22/24/13384 |
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