Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming
Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human...
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Bibliographic Details
| Main Authors: |
Irene Cantone,
Hakan Bagci,
Dirk Dormann,
Gopuraja Dharmalingam,
Tatyana Nesterova,
Neil Brockdorff,
Claire Rougeulle,
Celine Vallot,
Edith Heard,
Ronan Chaligne,
Matthias Merkenschlager,
Amanda G. Fisher |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12354
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