Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming
Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12354 |
| _version_ | 1819194692583030784 |
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| author | Irene Cantone Hakan Bagci Dirk Dormann Gopuraja Dharmalingam Tatyana Nesterova Neil Brockdorff Claire Rougeulle Celine Vallot Edith Heard Ronan Chaligne Matthias Merkenschlager Amanda G. Fisher |
| author_facet | Irene Cantone Hakan Bagci Dirk Dormann Gopuraja Dharmalingam Tatyana Nesterova Neil Brockdorff Claire Rougeulle Celine Vallot Edith Heard Ronan Chaligne Matthias Merkenschlager Amanda G. Fisher |
| author_sort | Irene Cantone |
| collection | DOAJ |
| description | Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human Xi chromosome. |
| first_indexed | 2024-12-23T02:00:54Z |
| format | Article |
| id | doaj.art-4e0f58511c414c589feb938c38b79712 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:00:54Z |
| publishDate | 2016-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4e0f58511c414c589feb938c38b797122022-12-21T18:03:59ZengNature PortfolioNature Communications2041-17232016-08-017111210.1038/ncomms12354Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogrammingIrene Cantone0Hakan Bagci1Dirk Dormann2Gopuraja Dharmalingam3Tatyana Nesterova4Neil Brockdorff5Claire Rougeulle6Celine Vallot7Edith Heard8Ronan Chaligne9Matthias Merkenschlager10Amanda G. Fisher11Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of MedicineLymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of MedicineMicroscopy Laboratory, MRC Clinical Sciences Centre, Imperial College School of MedicineBioinformatics and Computing facility, MRC Clinical Sciences Centre, Imperial CollegeDepartment of Biochemistry, Developmental Epigenetics Group, University of OxfordDepartment of Biochemistry, Developmental Epigenetics Group, University of OxfordEpigenetics and Cell Fate, CNRS UMR7216, Université Paris DiderotEpigenetics and Cell Fate, CNRS UMR7216, Université Paris DiderotMammalian Developmental Epigenetics Group, Institut CurieMammalian Developmental Epigenetics Group, Institut CurieLymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of MedicineLymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of MedicineReactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human Xi chromosome.https://doi.org/10.1038/ncomms12354 |
| spellingShingle | Irene Cantone Hakan Bagci Dirk Dormann Gopuraja Dharmalingam Tatyana Nesterova Neil Brockdorff Claire Rougeulle Celine Vallot Edith Heard Ronan Chaligne Matthias Merkenschlager Amanda G. Fisher Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming Nature Communications |
| title | Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming |
| title_full | Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming |
| title_fullStr | Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming |
| title_full_unstemmed | Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming |
| title_short | Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming |
| title_sort | ordered chromatin changes and human x chromosome reactivation by cell fusion mediated pluripotent reprogramming |
| url | https://doi.org/10.1038/ncomms12354 |
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