Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis

In 1921; Masson and Maresch first coined the term “neurogenic appendicitis (NA)” to describe “neuroma-like” lesions in the appendix. To date, our knowledge about NA is limited; therefore, we conducted a comprehensive analysis of the literature (1921 to 2020) to examine the clinicopathological featur...

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Main Authors: Mahmoud Rezk Abdelwahed Hussein, Ali Al Bshabshe, Ahmed Abdelsatar Elhakeem, Mahmoud Kamal Elsamman
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Diagnostics
Subjects:
Online Access:https://www.mdpi.com/2075-4418/12/6/1386
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author Mahmoud Rezk Abdelwahed Hussein
Ali Al Bshabshe
Ahmed Abdelsatar Elhakeem
Mahmoud Kamal Elsamman
author_facet Mahmoud Rezk Abdelwahed Hussein
Ali Al Bshabshe
Ahmed Abdelsatar Elhakeem
Mahmoud Kamal Elsamman
author_sort Mahmoud Rezk Abdelwahed Hussein
collection DOAJ
description In 1921; Masson and Maresch first coined the term “neurogenic appendicitis (NA)” to describe “neuroma-like” lesions in the appendix. To date, our knowledge about NA is limited; therefore, we conducted a comprehensive analysis of the literature (1921 to 2020) to examine the clinicopathological features of NA. We also addressed the pathophysiology of acute abdominal pain and fibrosis in this entity. We performed a meta-analysis study by searching the PubMed database, using several keywords, such as: “appendix,” “neurogenic,” “obliterative,” “neuroma,” “fibrous obliteration,” “appendicopathy,” and “appendicitis.” Our study revealed that patients with NA usually present clinically with features of acute appendicitis, bud2t they have grossly unremarkable appendices. Histologically, the central appendiceal neuroma was the most common histological variant of NA, followed by the submucosal and intramucosal variants. To conclude, NA represents a form of neuroinflammation. The possibility of NA should be considered in patients with clinical features of acute appendicitis who intraoperatively show a grossly unremarkable appendix. Neuroinflammation and neuropeptides play roles in the development of pain and fibrosis in NA.
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spelling doaj.art-4e10a2afe0e549218dd8a07142bcd5ee2023-11-23T16:17:18ZengMDPI AGDiagnostics2075-44182022-06-01126138610.3390/diagnostics12061386Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and PathogenesisMahmoud Rezk Abdelwahed Hussein0Ali Al Bshabshe1Ahmed Abdelsatar Elhakeem2Mahmoud Kamal Elsamman3Department of Pathology, Assiut University Hospitals, Assiut 71515, EgyptDepartment of Medicine, College of Medicine, King Khalid University, Abha 62527, Saudi ArabiaDepartment of Pathology, Alazhar University, Cairo 11884, EgyptDepartment of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82725, EgyptIn 1921; Masson and Maresch first coined the term “neurogenic appendicitis (NA)” to describe “neuroma-like” lesions in the appendix. To date, our knowledge about NA is limited; therefore, we conducted a comprehensive analysis of the literature (1921 to 2020) to examine the clinicopathological features of NA. We also addressed the pathophysiology of acute abdominal pain and fibrosis in this entity. We performed a meta-analysis study by searching the PubMed database, using several keywords, such as: “appendix,” “neurogenic,” “obliterative,” “neuroma,” “fibrous obliteration,” “appendicopathy,” and “appendicitis.” Our study revealed that patients with NA usually present clinically with features of acute appendicitis, bud2t they have grossly unremarkable appendices. Histologically, the central appendiceal neuroma was the most common histological variant of NA, followed by the submucosal and intramucosal variants. To conclude, NA represents a form of neuroinflammation. The possibility of NA should be considered in patients with clinical features of acute appendicitis who intraoperatively show a grossly unremarkable appendix. Neuroinflammation and neuropeptides play roles in the development of pain and fibrosis in NA.https://www.mdpi.com/2075-4418/12/6/1386appendixneurogenicneuroinflammation
spellingShingle Mahmoud Rezk Abdelwahed Hussein
Ali Al Bshabshe
Ahmed Abdelsatar Elhakeem
Mahmoud Kamal Elsamman
Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis
Diagnostics
appendix
neurogenic
neuroinflammation
title Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis
title_full Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis
title_fullStr Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis
title_full_unstemmed Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis
title_short Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis
title_sort neurogenic appendicitis a reappraisal of the clinicopathological features and pathogenesis
topic appendix
neurogenic
neuroinflammation
url https://www.mdpi.com/2075-4418/12/6/1386
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AT ahmedabdelsatarelhakeem neurogenicappendicitisareappraisaloftheclinicopathologicalfeaturesandpathogenesis
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