Islet cilia and glucose homeostasis

Diabetes is a growing pandemic affecting over ten percent of the U.S. population. Individuals with all types of diabetes exhibit glucose dysregulation due to altered function and coordination of pancreatic islets. Within the critical intercellular space in pancreatic islets, the primary cilium emerg...

Full description

Bibliographic Details
Main Authors: Isabella Melena, Jing W. Hughes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1082193/full
_version_ 1798014828801949696
author Isabella Melena
Jing W. Hughes
author_facet Isabella Melena
Jing W. Hughes
author_sort Isabella Melena
collection DOAJ
description Diabetes is a growing pandemic affecting over ten percent of the U.S. population. Individuals with all types of diabetes exhibit glucose dysregulation due to altered function and coordination of pancreatic islets. Within the critical intercellular space in pancreatic islets, the primary cilium emerges as an important physical structure mediating cell-cell crosstalk and signal transduction. Many events leading to hormone secretion, including GPCR and second-messenger signaling, are spatiotemporally regulated at the level of the cilium. In this review, we summarize current knowledge of cilia action in islet hormone regulation and glucose homeostasis, focusing on newly implicated ciliary pathways that regulate insulin exocytosis and intercellular communication. We present evidence of key signaling proteins on islet cilia and discuss ways in which cilia might functionally connect islet endocrine cells with the non-endocrine compartments. These discussions aim to stimulate conversations regarding the extent of cilia-controlled glucose homeostasis in health and in metabolic diseases.
first_indexed 2024-04-11T15:24:37Z
format Article
id doaj.art-4e117138166646689f2b7b6edd9fa4fc
institution Directory Open Access Journal
issn 2296-634X
language English
last_indexed 2024-04-11T15:24:37Z
publishDate 2022-12-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Cell and Developmental Biology
spelling doaj.art-4e117138166646689f2b7b6edd9fa4fc2022-12-22T04:16:18ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10821931082193Islet cilia and glucose homeostasisIsabella MelenaJing W. HughesDiabetes is a growing pandemic affecting over ten percent of the U.S. population. Individuals with all types of diabetes exhibit glucose dysregulation due to altered function and coordination of pancreatic islets. Within the critical intercellular space in pancreatic islets, the primary cilium emerges as an important physical structure mediating cell-cell crosstalk and signal transduction. Many events leading to hormone secretion, including GPCR and second-messenger signaling, are spatiotemporally regulated at the level of the cilium. In this review, we summarize current knowledge of cilia action in islet hormone regulation and glucose homeostasis, focusing on newly implicated ciliary pathways that regulate insulin exocytosis and intercellular communication. We present evidence of key signaling proteins on islet cilia and discuss ways in which cilia might functionally connect islet endocrine cells with the non-endocrine compartments. These discussions aim to stimulate conversations regarding the extent of cilia-controlled glucose homeostasis in health and in metabolic diseases.https://www.frontiersin.org/articles/10.3389/fcell.2022.1082193/fullprimary ciliabeta cellspancreatic isletsparacrine signalingglucose regulation
spellingShingle Isabella Melena
Jing W. Hughes
Islet cilia and glucose homeostasis
Frontiers in Cell and Developmental Biology
primary cilia
beta cells
pancreatic islets
paracrine signaling
glucose regulation
title Islet cilia and glucose homeostasis
title_full Islet cilia and glucose homeostasis
title_fullStr Islet cilia and glucose homeostasis
title_full_unstemmed Islet cilia and glucose homeostasis
title_short Islet cilia and glucose homeostasis
title_sort islet cilia and glucose homeostasis
topic primary cilia
beta cells
pancreatic islets
paracrine signaling
glucose regulation
url https://www.frontiersin.org/articles/10.3389/fcell.2022.1082193/full
work_keys_str_mv AT isabellamelena isletciliaandglucosehomeostasis
AT jingwhughes isletciliaandglucosehomeostasis