Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis
Background: Patients with psoriasis might be at a higher risk of developing Parkinson's disease (PD) as a result of the detrimental effect of chronic inflammation on the neuronal tissue. This meta-analysis aimed to investigate this risk by comprehensively reviewing all available data. Methods:...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=152;epage=157;aulast=Ungprasert |
| _version_ | 1818520920563646464 |
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| author | Patompong Ungprasert Narat Srivali Wonngarm Kittanamongkolchai |
| author_facet | Patompong Ungprasert Narat Srivali Wonngarm Kittanamongkolchai |
| author_sort | Patompong Ungprasert |
| collection | DOAJ |
| description | Background: Patients with psoriasis might be at a higher risk of developing Parkinson's disease (PD) as a result of the detrimental effect of chronic inflammation on the neuronal tissue. This meta-analysis aimed to investigate this risk by comprehensively reviewing all available data. Methods: We conducted a systematic review and meta-analysis of cohort and case–control studies that reported relative risk, hazard ratio, odds ratio, or standardized incidence ratio comparing the risk of PD in patients with psoriasis versus subjects without psoriasis. Pooled risk ratio and 95% confidence interval (CI) were calculated using random-effect, generic inverse variance methods of DerSimonian and Laird. Results: Three retrospective studies and one case–control study met our eligibility criteria and were included in this meta-analysis. The pooled risk ratio of PD in patients with psoriasis versus participants without psoriasis was 1.38 (95% CI, 1.15–1.66). The statistical heterogeneity was low with an I2of 35%. Conclusions: Our meta-analysis demonstrated a statistically significant increased risk of PD among patients with psoriasis. |
| first_indexed | 2024-12-11T01:44:06Z |
| format | Article |
| id | doaj.art-4e11eec929b74e2eb86bc847da3683a1 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-11T01:44:06Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-4e11eec929b74e2eb86bc847da3683a12022-12-22T01:24:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112016-01-0161215215710.4103/0019-5154.177771Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysisPatompong UngprasertNarat SrivaliWonngarm KittanamongkolchaiBackground: Patients with psoriasis might be at a higher risk of developing Parkinson's disease (PD) as a result of the detrimental effect of chronic inflammation on the neuronal tissue. This meta-analysis aimed to investigate this risk by comprehensively reviewing all available data. Methods: We conducted a systematic review and meta-analysis of cohort and case–control studies that reported relative risk, hazard ratio, odds ratio, or standardized incidence ratio comparing the risk of PD in patients with psoriasis versus subjects without psoriasis. Pooled risk ratio and 95% confidence interval (CI) were calculated using random-effect, generic inverse variance methods of DerSimonian and Laird. Results: Three retrospective studies and one case–control study met our eligibility criteria and were included in this meta-analysis. The pooled risk ratio of PD in patients with psoriasis versus participants without psoriasis was 1.38 (95% CI, 1.15–1.66). The statistical heterogeneity was low with an I2of 35%. Conclusions: Our meta-analysis demonstrated a statistically significant increased risk of PD among patients with psoriasis.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=152;epage=157;aulast=UngprasertEpidemiologyParkinson's diseasepsoriasisrisk factor |
| spellingShingle | Patompong Ungprasert Narat Srivali Wonngarm Kittanamongkolchai Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis Indian Journal of Dermatology Epidemiology Parkinson's disease psoriasis risk factor |
| title | Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis |
| title_full | Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis |
| title_fullStr | Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis |
| title_full_unstemmed | Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis |
| title_short | Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis |
| title_sort | risk of parkinson s disease among patients with psoriasis a systematic review and meta analysis |
| topic | Epidemiology Parkinson's disease psoriasis risk factor |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=152;epage=157;aulast=Ungprasert |
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