Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson’s Disease Rat Model

Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson’s Disease Rat Model

Persistent pain is a prevalent symptom of Parkinson’s disease (PD), which is related to the loss of monoamines and neuroinflammation. Motor cortex stimulation (MCS) inhibits persistent pain by activating the descending analgesic pathways; however, its effectiveness in the control of PD-induced pain...

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Bibliographic Details
Main Authors: Ana Carolina P. Campos, Miriã B. Berzuíno, Gabriela R. Barbosa, Helena M. R. C. Freire, Patricia S. Lopes, Danielle V. Assis, Erich T. Fonoff, Rosana L. Pagano
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
motor cortex
epidural stimulation
pain control
Parkinson’s disease
serotonin
glial cells
Online Access:https://www.mdpi.com/2073-4409/10/5/1158

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