Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury
Introduction: Dizziness and balance impairment are common symptoms of mild traumatic brain injury (mTBI). Acid-sensing ion channel 3 (ASIC3) is expressed in the vestibular and proprioceptive systems and associated with balance functions. However, whether the genetic variants of ASIC3 are associated...
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00088/full |
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| author | Hsun-Hua Lee Hsun-Hua Lee Hsun-Hua Lee Hsun-Hua Lee Hon-Ping Ma Hon-Ping Ma Hon-Ping Ma Ju-Chi Ou Jiann Ruey Ong Jiann Ruey Ong Kai-Yun Chen Chung-Che Wu Wen-Ta Chiu Kuo-Hsing Liao Chien-Min Lin Shu-Yu Lin Dean Wu Dean Wu Dean Wu Dean Wu Yao-Hsien Huang Yao-Hsien Huang Yao-Hsien Huang Yuan-Hung Wang Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chien-Tai Hong Chien-Tai Hong Chien-Tai Hong |
| author_facet | Hsun-Hua Lee Hsun-Hua Lee Hsun-Hua Lee Hsun-Hua Lee Hon-Ping Ma Hon-Ping Ma Hon-Ping Ma Ju-Chi Ou Jiann Ruey Ong Jiann Ruey Ong Kai-Yun Chen Chung-Che Wu Wen-Ta Chiu Kuo-Hsing Liao Chien-Min Lin Shu-Yu Lin Dean Wu Dean Wu Dean Wu Dean Wu Yao-Hsien Huang Yao-Hsien Huang Yao-Hsien Huang Yuan-Hung Wang Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chien-Tai Hong Chien-Tai Hong Chien-Tai Hong |
| author_sort | Hsun-Hua Lee |
| collection | DOAJ |
| description | Introduction: Dizziness and balance impairment are common symptoms of mild traumatic brain injury (mTBI). Acid-sensing ion channel 3 (ASIC3) is expressed in the vestibular and proprioceptive systems and associated with balance functions. However, whether the genetic variants of ASIC3 are associated with people who suffer dizziness and balance impairment after mTBI remained unknown.Materials and methods: A total of 200 people with mTBI and 109 non-mTBI controls were recruited. Dizziness, balance functions, and the ability to perform daily activities were assessed by Dizziness Handicap Inventory (DHI), and objective balance functions were investigated by the postural stability test. Three diseases-related genetic variants of ASIC3 were determined through polymerase chain reaction and followed by restriction fragment length polymorphism. The Student's t-test and Mann-Whitney U-test were used for normal and abnormal distributed data, respectively. The regression was applied to adjust gender and age. The normality of continuous data was evaluated by Shapiro-Wilk test.Results: In the mTBI people, the rs2288645-A allele carriers exhibited a significantly worse physical domain DHI score (A-allele carriers: 11.39 ± 8.42, non-A carriers: 8.76 ± 7.87, p = 0.03). The rs4148855-GTC deletion carriers an exhibited significantly worse overall postural stability (GTC deletion carriers: 0.53 ± 0.33, non-carriers: 0.46 ± 0.20, p = 0.03). In the controls, rs2288646-A allele carriers were significant worse in the medial-to-lateral postural stability (A-allele carriers: 0.31 ± 0.17, non-A carriers: 0.21 ± 0.10, p = 0.01).Conclusion: The present study demonstrated that ASIC3 genetic variants were associated with certain aspects of balance functions and dizziness questionnaires in people of mTBI and non-mTBI. It provides a possible evidence that ASIC3 could be a new target for the management of the balancing disorders. However, further investigations are warranted to elucidate the underlying mechanisms and clinical significance. |
| first_indexed | 2024-12-14T18:12:08Z |
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| id | doaj.art-4e149e4c44064b5198fc23ec0bfd7305 |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T18:12:08Z |
| publishDate | 2019-02-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-4e149e4c44064b5198fc23ec0bfd73052022-12-21T22:52:15ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-02-011010.3389/fneur.2019.00088425566Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain InjuryHsun-Hua Lee0Hsun-Hua Lee1Hsun-Hua Lee2Hsun-Hua Lee3Hon-Ping Ma4Hon-Ping Ma5Hon-Ping Ma6Ju-Chi Ou7Jiann Ruey Ong8Jiann Ruey Ong9Kai-Yun Chen10Chung-Che Wu11Wen-Ta Chiu12Kuo-Hsing Liao13Chien-Min Lin14Shu-Yu Lin15Dean Wu16Dean Wu17Dean Wu18Dean Wu19Yao-Hsien Huang20Yao-Hsien Huang21Yao-Hsien Huang22Yuan-Hung Wang23Chaur-Jong Hu24Chaur-Jong Hu25Chaur-Jong Hu26Chien-Tai Hong27Chien-Tai Hong28Chien-Tai Hong29College of Medicine, Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDizziness and Balance Disorder Center, Taipei Medical University–Shuang Ho Hospital, New Taipei City, TaiwanDepartment of Emergency Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCollege of Public Health and Nutrition, Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, TaiwanDepartment of Emergency Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Emergency Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCollege of Medical Science and Technology, Graduate Institute of Neural Regenerative Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurosurgery, Taipei Medical University, Taipei, TaiwanCollege of Public Health and Nutrition, Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan0Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan1Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan2Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDizziness and Balance Disorder Center, Taipei Medical University–Shuang Ho Hospital, New Taipei City, Taiwan3Sleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDizziness and Balance Disorder Center, Taipei Medical University–Shuang Ho Hospital, New Taipei City, TaiwanCollege of Medicine, Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDizziness and Balance Disorder Center, Taipei Medical University–Shuang Ho Hospital, New Taipei City, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDizziness and Balance Disorder Center, Taipei Medical University–Shuang Ho Hospital, New Taipei City, TaiwanIntroduction: Dizziness and balance impairment are common symptoms of mild traumatic brain injury (mTBI). Acid-sensing ion channel 3 (ASIC3) is expressed in the vestibular and proprioceptive systems and associated with balance functions. However, whether the genetic variants of ASIC3 are associated with people who suffer dizziness and balance impairment after mTBI remained unknown.Materials and methods: A total of 200 people with mTBI and 109 non-mTBI controls were recruited. Dizziness, balance functions, and the ability to perform daily activities were assessed by Dizziness Handicap Inventory (DHI), and objective balance functions were investigated by the postural stability test. Three diseases-related genetic variants of ASIC3 were determined through polymerase chain reaction and followed by restriction fragment length polymorphism. The Student's t-test and Mann-Whitney U-test were used for normal and abnormal distributed data, respectively. The regression was applied to adjust gender and age. The normality of continuous data was evaluated by Shapiro-Wilk test.Results: In the mTBI people, the rs2288645-A allele carriers exhibited a significantly worse physical domain DHI score (A-allele carriers: 11.39 ± 8.42, non-A carriers: 8.76 ± 7.87, p = 0.03). The rs4148855-GTC deletion carriers an exhibited significantly worse overall postural stability (GTC deletion carriers: 0.53 ± 0.33, non-carriers: 0.46 ± 0.20, p = 0.03). In the controls, rs2288646-A allele carriers were significant worse in the medial-to-lateral postural stability (A-allele carriers: 0.31 ± 0.17, non-A carriers: 0.21 ± 0.10, p = 0.01).Conclusion: The present study demonstrated that ASIC3 genetic variants were associated with certain aspects of balance functions and dizziness questionnaires in people of mTBI and non-mTBI. It provides a possible evidence that ASIC3 could be a new target for the management of the balancing disorders. However, further investigations are warranted to elucidate the underlying mechanisms and clinical significance.https://www.frontiersin.org/article/10.3389/fneur.2019.00088/fullmTBI (mild traumatic brain injury)dizzinessbalance functionASIC3stabilitysensory integration |
| spellingShingle | Hsun-Hua Lee Hsun-Hua Lee Hsun-Hua Lee Hsun-Hua Lee Hon-Ping Ma Hon-Ping Ma Hon-Ping Ma Ju-Chi Ou Jiann Ruey Ong Jiann Ruey Ong Kai-Yun Chen Chung-Che Wu Wen-Ta Chiu Kuo-Hsing Liao Chien-Min Lin Shu-Yu Lin Dean Wu Dean Wu Dean Wu Dean Wu Yao-Hsien Huang Yao-Hsien Huang Yao-Hsien Huang Yuan-Hung Wang Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chien-Tai Hong Chien-Tai Hong Chien-Tai Hong Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury Frontiers in Neurology mTBI (mild traumatic brain injury) dizziness balance function ASIC3 stability sensory integration |
| title | Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury |
| title_full | Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury |
| title_fullStr | Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury |
| title_full_unstemmed | Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury |
| title_short | Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury |
| title_sort | association between acid sensing ion channel 3 gene variants and balance impairment in people with mild traumatic brain injury |
| topic | mTBI (mild traumatic brain injury) dizziness balance function ASIC3 stability sensory integration |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00088/full |
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