The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy
Many clinical studies have now highlighted how the composition of the intestinal microbiota can regulate the effects of many oncological therapies. In particular, the modulation of microbial composition has been shown to enhance their efficacy and reduce potential side effects. Numerous adverse even...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/4/2306 |
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| author | Massimiliano Cazzaniga Marco Cardinali Francesco Di Pierro Giordano Bruno Zonzini Chiara Maria Palazzi Aurora Gregoretti Nicola Zerbinati Luigina Guasti Alexander Bertuccioli |
| author_facet | Massimiliano Cazzaniga Marco Cardinali Francesco Di Pierro Giordano Bruno Zonzini Chiara Maria Palazzi Aurora Gregoretti Nicola Zerbinati Luigina Guasti Alexander Bertuccioli |
| author_sort | Massimiliano Cazzaniga |
| collection | DOAJ |
| description | Many clinical studies have now highlighted how the composition of the intestinal microbiota can regulate the effects of many oncological therapies. In particular, the modulation of microbial composition has been shown to enhance their efficacy and reduce potential side effects. Numerous adverse events induced by chemotherapy and radiotherapy appear to be strongly associated with an alteration in the intestinal microbiota caused by these treatments. This supports the hypothesis that the modulation or correction of the microbiota may decrease the toxic impact of therapies, improving patient compliance and quality of life. Among the most debilitating disorders related to oncological treatments is certainly mucositis, and recent clinical data highlight how the deficiency of short-chain fatty acids, especially butyrate, and specifically the lack of certain bacterial groups responsible for its production (butyrate producers), is strongly associated with this disorder. It is hypothesized that restoring these elements may influence the onset and severity of adverse events. Therefore, the intake of probiotics, especially butyrate producers, and specifically <i>Clostridium butyricum</i> (CBM588), currently the only cultivable and usable strain with a history of data proving its safety, could be a valuable ally in oncological therapies, reducing the associated discomfort and improving compliance, efficacy, and quality of life for patients. |
| first_indexed | 2024-03-07T22:28:31Z |
| format | Article |
| id | doaj.art-4e1635a8ffc146378e838f1909871555 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:28:31Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4e1635a8ffc146378e838f19098715552024-02-23T15:20:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254230610.3390/ijms25042306The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-RadiotherapyMassimiliano Cazzaniga0Marco Cardinali1Francesco Di Pierro2Giordano Bruno Zonzini3Chiara Maria Palazzi4Aurora Gregoretti5Nicola Zerbinati6Luigina Guasti7Alexander Bertuccioli8Scientific & Research Department, Velleja Research, 20125 Milano, ItalyDepartment of Internal Medicine, Infermi Hospital, AUSL Romagna, 47921 Rimini, ItalyScientific & Research Department, Velleja Research, 20125 Milano, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61122 Urbino, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyDepartment of Medicine and Surgery, University of Insurbia, 21100 Varese, ItalyDepartment of Medicine and Surgery, University of Insurbia, 21100 Varese, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMany clinical studies have now highlighted how the composition of the intestinal microbiota can regulate the effects of many oncological therapies. In particular, the modulation of microbial composition has been shown to enhance their efficacy and reduce potential side effects. Numerous adverse events induced by chemotherapy and radiotherapy appear to be strongly associated with an alteration in the intestinal microbiota caused by these treatments. This supports the hypothesis that the modulation or correction of the microbiota may decrease the toxic impact of therapies, improving patient compliance and quality of life. Among the most debilitating disorders related to oncological treatments is certainly mucositis, and recent clinical data highlight how the deficiency of short-chain fatty acids, especially butyrate, and specifically the lack of certain bacterial groups responsible for its production (butyrate producers), is strongly associated with this disorder. It is hypothesized that restoring these elements may influence the onset and severity of adverse events. Therefore, the intake of probiotics, especially butyrate producers, and specifically <i>Clostridium butyricum</i> (CBM588), currently the only cultivable and usable strain with a history of data proving its safety, could be a valuable ally in oncological therapies, reducing the associated discomfort and improving compliance, efficacy, and quality of life for patients.https://www.mdpi.com/1422-0067/25/4/2306probioticsbutyratemucositisradiotherapychemotherapy |
| spellingShingle | Massimiliano Cazzaniga Marco Cardinali Francesco Di Pierro Giordano Bruno Zonzini Chiara Maria Palazzi Aurora Gregoretti Nicola Zerbinati Luigina Guasti Alexander Bertuccioli The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy International Journal of Molecular Sciences probiotics butyrate mucositis radiotherapy chemotherapy |
| title | The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy |
| title_full | The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy |
| title_fullStr | The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy |
| title_full_unstemmed | The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy |
| title_short | The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy |
| title_sort | potential role of probiotics especially butyrate producers in the management of gastrointestinal mucositis induced by oncologic chemo radiotherapy |
| topic | probiotics butyrate mucositis radiotherapy chemotherapy |
| url | https://www.mdpi.com/1422-0067/25/4/2306 |
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