Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy
BackgroundThe present work evaluated how Peking prognostic score (PPS), the new prognostic index determined according to sarcopenia and lymphocyte-to-C-reactive protein ratio (LCR), was a prognostic factor for patients with gastric cancer liver metastases (GCLM) who received hepatectomy.MethodsThis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.976364/full |
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| author | Jianping Xiong Yunzi Wu Haitao Hu Wenzhe Kang Yang Li Peng Jin Xinxin Shao Weikun Li Yibin Xie Yantao Tian |
| author_facet | Jianping Xiong Yunzi Wu Haitao Hu Wenzhe Kang Yang Li Peng Jin Xinxin Shao Weikun Li Yibin Xie Yantao Tian |
| author_sort | Jianping Xiong |
| collection | DOAJ |
| description | BackgroundThe present work evaluated how Peking prognostic score (PPS), the new prognostic index determined according to sarcopenia and lymphocyte-to-C-reactive protein ratio (LCR), was a prognostic factor for patients with gastric cancer liver metastases (GCLM) who received hepatectomy.MethodsThis work extracted information about patients with GCLM who underwent hepatectomy from June 2012 to May 2018. The PPS of the patients was calculated from sarcopenia status and LCR before surgery, and patients were then divided into three groups based on their PPS. This work also carried out univariate and multivariate analyses for identifying variables that were linked with overall survival (OS) together with recurrence-free survival (RFS) after hepatectomy among three groups according to PPS.ResultsThis work included 108 GCLM cases who received hepatectomy. All cases were classified into 3 groups, i.e., 26 (24.1%), 48 (44.4%), and 34 (31.5%) in groups 0–2, separately. PPS exhibited positive relation with age (p < 0.001), body mass index (BMI; p = 0.012), and liver metastasis number. The relapse rate after hepatectomy in patients with GCLM was 69.4%. Additionally, the remnant liver relapse rates of groups 0–2 were 80.0, 68.7, and 53.5%. Patients in group 0 had significantly increased remnant liver relapse rates when compared with those in groups 0 and 1. PPS was significantly related to relapse patterns (p = 0.003). Relative to group 0, those of the other 2 groups showed dismal OS [hazard ratio (HR) = 3.98, 7.49 for groups 1 and 2; p < 0.001] along with RFS (HR = 3.65, 5.33 for groups 1 and 2; p < 0.001). As revealed by multivariate analysis, PPS independently predicted OS (p < 0.001) together with RFS (p < 0.001).ConclusionThe PPS could be an easy nutrition-inflammation prognostic scoring system and an independent preoperative predictor of survival for GCLM cases after hepatectomy. |
| first_indexed | 2024-04-12T16:56:38Z |
| format | Article |
| id | doaj.art-4e1680c0aebf4ae08d6840f00ac08511 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T16:56:38Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-4e1680c0aebf4ae08d6840f00ac085112022-12-22T03:24:12ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.976364976364Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomyJianping XiongYunzi WuHaitao HuWenzhe KangYang LiPeng JinXinxin ShaoWeikun LiYibin XieYantao TianBackgroundThe present work evaluated how Peking prognostic score (PPS), the new prognostic index determined according to sarcopenia and lymphocyte-to-C-reactive protein ratio (LCR), was a prognostic factor for patients with gastric cancer liver metastases (GCLM) who received hepatectomy.MethodsThis work extracted information about patients with GCLM who underwent hepatectomy from June 2012 to May 2018. The PPS of the patients was calculated from sarcopenia status and LCR before surgery, and patients were then divided into three groups based on their PPS. This work also carried out univariate and multivariate analyses for identifying variables that were linked with overall survival (OS) together with recurrence-free survival (RFS) after hepatectomy among three groups according to PPS.ResultsThis work included 108 GCLM cases who received hepatectomy. All cases were classified into 3 groups, i.e., 26 (24.1%), 48 (44.4%), and 34 (31.5%) in groups 0–2, separately. PPS exhibited positive relation with age (p < 0.001), body mass index (BMI; p = 0.012), and liver metastasis number. The relapse rate after hepatectomy in patients with GCLM was 69.4%. Additionally, the remnant liver relapse rates of groups 0–2 were 80.0, 68.7, and 53.5%. Patients in group 0 had significantly increased remnant liver relapse rates when compared with those in groups 0 and 1. PPS was significantly related to relapse patterns (p = 0.003). Relative to group 0, those of the other 2 groups showed dismal OS [hazard ratio (HR) = 3.98, 7.49 for groups 1 and 2; p < 0.001] along with RFS (HR = 3.65, 5.33 for groups 1 and 2; p < 0.001). As revealed by multivariate analysis, PPS independently predicted OS (p < 0.001) together with RFS (p < 0.001).ConclusionThe PPS could be an easy nutrition-inflammation prognostic scoring system and an independent preoperative predictor of survival for GCLM cases after hepatectomy.https://www.frontiersin.org/articles/10.3389/fnut.2022.976364/fullgastric cancerliver metastaseshepatectomyPeking prognostic scoreprognostic scoring system |
| spellingShingle | Jianping Xiong Yunzi Wu Haitao Hu Wenzhe Kang Yang Li Peng Jin Xinxin Shao Weikun Li Yibin Xie Yantao Tian Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy Frontiers in Nutrition gastric cancer liver metastases hepatectomy Peking prognostic score prognostic scoring system |
| title | Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy |
| title_full | Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy |
| title_fullStr | Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy |
| title_full_unstemmed | Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy |
| title_short | Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy |
| title_sort | peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy |
| topic | gastric cancer liver metastases hepatectomy Peking prognostic score prognostic scoring system |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.976364/full |
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