Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation
Abstract Objective To investigate the prognostic factors of patients with pancreatic neuroendocrine tumor (pNETs) after surgical resection, and to analyze the value of enucleation for pNETs without distant metastasis that are well-differentiated (G1) and have a diameter ≤ 4 cm. Methods Data from pNE...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-020-02115-z |
| _version_ | 1819052144686268416 |
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| author | Junzhang Chen Yongyu Yang Yuanhua Liu Heping Kan |
| author_facet | Junzhang Chen Yongyu Yang Yuanhua Liu Heping Kan |
| author_sort | Junzhang Chen |
| collection | DOAJ |
| description | Abstract Objective To investigate the prognostic factors of patients with pancreatic neuroendocrine tumor (pNETs) after surgical resection, and to analyze the value of enucleation for pNETs without distant metastasis that are well-differentiated (G1) and have a diameter ≤ 4 cm. Methods Data from pNET patients undergoing surgical resection between 2004 and 2017 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan–Meier analysis and log-rank testing were used for the survival comparisons. Adjusted HRs with 95% CIs were calculated using univariate and multivariate Cox regression models to estimate the prognostic factors. P < 0.05 was regarded as statistically significant. Results This study found that female, cases diagnosed after 2010, and pancreatic body/tail tumors were protective factors for good survival, while histological grade G3, a larger tumor size, distant metastasis, AJCC 8th stage III-IV and age over 60 were independent prognostic factors for a worse OS/CSS. For the pNETs that were well-differentiated (G1) and had a tumor diameter ≤ 4 cm, the type of surgery was an independent factor for the long-term prognosis of this group. Compared with pancreaticoduodenectomy and total pancreatectomy, patients who were accepted enucleation had better OS/CSS. Conclusion For pNETs patients undergoing surgical resection, sex, year of diagnosis, tumor location, pathological grade, tumor size, distant metastasis, race, and age were independent prognostic factors associated with the OS/CSS of patients. For pNETs patients with G1 and a tumor diameter less than 4 cm, if the tumor was located over 3 mm from the pancreatic duct, enucleation may be a wise choice. |
| first_indexed | 2024-12-21T12:15:10Z |
| format | Article |
| id | doaj.art-4e1a015530f14720842f425556e82463 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-21T12:15:10Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-4e1a015530f14720842f425556e824632022-12-21T19:04:28ZengBMCWorld Journal of Surgical Oncology1477-78192021-01-0119111110.1186/s12957-020-02115-zPrognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleationJunzhang Chen0Yongyu Yang1Yuanhua Liu2Heping Kan3Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical UniversityAbstract Objective To investigate the prognostic factors of patients with pancreatic neuroendocrine tumor (pNETs) after surgical resection, and to analyze the value of enucleation for pNETs without distant metastasis that are well-differentiated (G1) and have a diameter ≤ 4 cm. Methods Data from pNET patients undergoing surgical resection between 2004 and 2017 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan–Meier analysis and log-rank testing were used for the survival comparisons. Adjusted HRs with 95% CIs were calculated using univariate and multivariate Cox regression models to estimate the prognostic factors. P < 0.05 was regarded as statistically significant. Results This study found that female, cases diagnosed after 2010, and pancreatic body/tail tumors were protective factors for good survival, while histological grade G3, a larger tumor size, distant metastasis, AJCC 8th stage III-IV and age over 60 were independent prognostic factors for a worse OS/CSS. For the pNETs that were well-differentiated (G1) and had a tumor diameter ≤ 4 cm, the type of surgery was an independent factor for the long-term prognosis of this group. Compared with pancreaticoduodenectomy and total pancreatectomy, patients who were accepted enucleation had better OS/CSS. Conclusion For pNETs patients undergoing surgical resection, sex, year of diagnosis, tumor location, pathological grade, tumor size, distant metastasis, race, and age were independent prognostic factors associated with the OS/CSS of patients. For pNETs patients with G1 and a tumor diameter less than 4 cm, if the tumor was located over 3 mm from the pancreatic duct, enucleation may be a wise choice.https://doi.org/10.1186/s12957-020-02115-zPancreatic neuroendocrine tumor (pNETs)Surveillance, epidemiology, end results (SEER) databaseSurgical resectionPrognostic factorEnucleation |
| spellingShingle | Junzhang Chen Yongyu Yang Yuanhua Liu Heping Kan Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation World Journal of Surgical Oncology Pancreatic neuroendocrine tumor (pNETs) Surveillance, epidemiology, end results (SEER) database Surgical resection Prognostic factor Enucleation |
| title | Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation |
| title_full | Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation |
| title_fullStr | Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation |
| title_full_unstemmed | Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation |
| title_short | Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation |
| title_sort | prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation |
| topic | Pancreatic neuroendocrine tumor (pNETs) Surveillance, epidemiology, end results (SEER) database Surgical resection Prognostic factor Enucleation |
| url | https://doi.org/10.1186/s12957-020-02115-z |
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