Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD)
Background: Previous studies have shown that garlic polysaccharides (GP) can protect the liver, but its mechanism is unclear. We are interested in whether it can alleviate metabolic associated fatty liver disease (MAFLD). Scope and approach: The MAFLD mice model was established by Methionine-choline...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622004121 |
| _version_ | 1811178925150175232 |
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| author | Jie Liu Wangning Yu Chenghai Wang Sha Li Wei Zhang |
| author_facet | Jie Liu Wangning Yu Chenghai Wang Sha Li Wei Zhang |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Background: Previous studies have shown that garlic polysaccharides (GP) can protect the liver, but its mechanism is unclear. We are interested in whether it can alleviate metabolic associated fatty liver disease (MAFLD). Scope and approach: The MAFLD mice model was established by Methionine-choline deficiency (MCD) diet induction. The experimental group was established by feeding with GP by gavage. The liver protective effect of GP and its possible mechanism were studied by means of microscopic examination, biochemical analysis, quantitative analysis of mRNA, metabolome, and gut microbiota analysis. Key Findings and Conclusion: GP treatment had a beneficial effect on hepatic injury and fat accumulation. Serum metabolome and gut microbiota analysis results indicate that GP had a significant proliferative effect on Faecalibaculum. In addition, GP also had a substantial impact on bile acid metabolic pathways. These findings provide new insights into the pathogenesis of MAFLD and provide further evidence for the potential use of GP as an alternative functional ingredient. |
| first_indexed | 2024-04-11T06:26:12Z |
| format | Article |
| id | doaj.art-4e1ad39b444d4620b6aa715482e12e4b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T06:26:12Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-4e1ad39b444d4620b6aa715482e12e4b2022-12-22T04:40:21ZengElsevierJournal of Functional Foods1756-46462022-12-0199105342Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD)Jie Liu0Wangning Yu1Chenghai Wang2Sha Li3Wei Zhang4College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China; School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, ChinaMedical College, Hebei University of Engineering, Handan 056038, China; Hebei Key Laboratory of Applied Basic Research of Blood Purification, Affiliated Hospital of Hebei Engineering University, Handan 056002, China; Corresponding authors at: Medical College, Hebei University of Engineering, Handan 056038, China (W. Yu). College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China (W. Zhang).Hebei Key Laboratory of Applied Basic Research of Blood Purification, Affiliated Hospital of Hebei Engineering University, Handan 056002, ChinaMedical College, Hebei University of Engineering, Handan 056038, China; Hebei Key Laboratory of Applied Basic Research of Blood Purification, Affiliated Hospital of Hebei Engineering University, Handan 056002, ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China; College of Life Sciences, Hebei Agricultural University, Baoding 071001, China; Corresponding authors at: Medical College, Hebei University of Engineering, Handan 056038, China (W. Yu). College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China (W. Zhang).Background: Previous studies have shown that garlic polysaccharides (GP) can protect the liver, but its mechanism is unclear. We are interested in whether it can alleviate metabolic associated fatty liver disease (MAFLD). Scope and approach: The MAFLD mice model was established by Methionine-choline deficiency (MCD) diet induction. The experimental group was established by feeding with GP by gavage. The liver protective effect of GP and its possible mechanism were studied by means of microscopic examination, biochemical analysis, quantitative analysis of mRNA, metabolome, and gut microbiota analysis. Key Findings and Conclusion: GP treatment had a beneficial effect on hepatic injury and fat accumulation. Serum metabolome and gut microbiota analysis results indicate that GP had a significant proliferative effect on Faecalibaculum. In addition, GP also had a substantial impact on bile acid metabolic pathways. These findings provide new insights into the pathogenesis of MAFLD and provide further evidence for the potential use of GP as an alternative functional ingredient.http://www.sciencedirect.com/science/article/pii/S1756464622004121Garlic Polysaccharides (GP)Metabolic Associated Fatty Liver Disease (MAFLD)Liver injuryGut microbiota |
| spellingShingle | Jie Liu Wangning Yu Chenghai Wang Sha Li Wei Zhang Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD) Journal of Functional Foods Garlic Polysaccharides (GP) Metabolic Associated Fatty Liver Disease (MAFLD) Liver injury Gut microbiota |
| title | Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD) |
| title_full | Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD) |
| title_fullStr | Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD) |
| title_full_unstemmed | Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD) |
| title_short | Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD) |
| title_sort | garlic allium sativum polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease mafld |
| topic | Garlic Polysaccharides (GP) Metabolic Associated Fatty Liver Disease (MAFLD) Liver injury Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622004121 |
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