Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα

Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα

Intronic polyadenylation (IPA) plays a critical role in malignant transformation, development, progression, and cancer chemoresistance by contributing to transcriptome/proteome alterations. DNA topoisomerase IIα (170 kDa, TOP2α/170) is an established clinical target for anticancer agents whose effic...

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Bibliographic Details
Main Authors: Terry S. Elton, Victor A. Hernandez, Jessika Carvajal-Moreno, Xinyi Wang, Deborah Ipinmoroti, Jack C. Yalowich
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
topoisomerase IIα
RNA splicing
alternative polyadenylation
intronic polyadenylation
CRISPR/Cas9
gene editing
Online Access:https://www.mdpi.com/2072-6694/14/13/3148

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