Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders
Aim. To study the features of the progression of atrial fibrillation (AF) in patients with arterial hypertension (HT) and comorbid extracardiac diseases.Material and methods. In the observational cohort study 308 men 45-65 years old with AF and HT were observed Most patients also had the following c...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2019-07-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1959 |
| _version_ | 1797232148073152512 |
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| author | L. D. Khidirova D. A. Yakhontov S. A. Zenin M. N. Mamedov |
| author_facet | L. D. Khidirova D. A. Yakhontov S. A. Zenin M. N. Mamedov |
| author_sort | L. D. Khidirova |
| collection | DOAJ |
| description | Aim. To study the features of the progression of atrial fibrillation (AF) in patients with arterial hypertension (HT) and comorbid extracardiac diseases.Material and methods. In the observational cohort study 308 men 45-65 years old with AF and HT were observed Most patients also had the following comorbid extracardiac diseases: diabetes mellitus (DM; n=40), diffuse toxic goiter (DTG; n=42); hypothyroidism (HTH; n=59), abdominal obesity (AO; n=64), and chronic obstructive pulmonary disease (COPD; n=47). The comparison group consisted of 56 patients with AF and HT only. Clinical, anthropometric, laboratory parameters, levels of NT-proBNP and galectin-3, results of ECG, daily monitoring of ECG and blood pressure wereassessed initially and after 12 months.Results. Persistent AF (29.6-65.2%) and long-term persistent AF (16-31.3%) were more common in groups with extracardiac diseases compared with the AF+HT group (20.4% and 14.2%, respectively). Permanent form of AF was statistically significantly more common in the DM (11.1%), AO (14.8%) and HTH (6.2%) groups compared with the AF+HT group (0.6%). A comparative assessment of risk factors (smoking and alcohol) did not show significant differences in prevalence in the groups (22-44%). An assessment of the levels of fibrosis and remodeling markers found a statistically significant increase in the level of galectin-3 in groups of patients with concomitant extracardiac diseases and an increase in the NT-proBNP level, relative to reference values in all groups except DTG.Conclusion. Patients with AF in combination with HT and comorbid extracardiac diseases have a more rapid AF progression. |
| first_indexed | 2024-03-08T14:01:56Z |
| format | Article |
| id | doaj.art-4e227437dcc84842849d344653965b5e |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:55:40Z |
| publishDate | 2019-07-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-4e227437dcc84842849d344653965b5e2024-04-01T07:43:38ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532019-07-0115336837310.20996/1819-6446-2019-15-3-368-3731617Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial DisordersL. D. Khidirova0D. A. Yakhontov1S. A. Zenin2M. N. Mamedov3Novosibirsk State Medical UniversityNovosibirsk State Medical UniversityNovosibirsk Regional Clinical Cardiology DispensaryNational Medical Research Center for Preventive MedicineAim. To study the features of the progression of atrial fibrillation (AF) in patients with arterial hypertension (HT) and comorbid extracardiac diseases.Material and methods. In the observational cohort study 308 men 45-65 years old with AF and HT were observed Most patients also had the following comorbid extracardiac diseases: diabetes mellitus (DM; n=40), diffuse toxic goiter (DTG; n=42); hypothyroidism (HTH; n=59), abdominal obesity (AO; n=64), and chronic obstructive pulmonary disease (COPD; n=47). The comparison group consisted of 56 patients with AF and HT only. Clinical, anthropometric, laboratory parameters, levels of NT-proBNP and galectin-3, results of ECG, daily monitoring of ECG and blood pressure wereassessed initially and after 12 months.Results. Persistent AF (29.6-65.2%) and long-term persistent AF (16-31.3%) were more common in groups with extracardiac diseases compared with the AF+HT group (20.4% and 14.2%, respectively). Permanent form of AF was statistically significantly more common in the DM (11.1%), AO (14.8%) and HTH (6.2%) groups compared with the AF+HT group (0.6%). A comparative assessment of risk factors (smoking and alcohol) did not show significant differences in prevalence in the groups (22-44%). An assessment of the levels of fibrosis and remodeling markers found a statistically significant increase in the level of galectin-3 in groups of patients with concomitant extracardiac diseases and an increase in the NT-proBNP level, relative to reference values in all groups except DTG.Conclusion. Patients with AF in combination with HT and comorbid extracardiac diseases have a more rapid AF progression.https://www.rpcardio.online/jour/article/view/1959atrial fibrillationarterial hypertensiondiabetes mellitusobesitythyroid glandchronic obstructive pulmonary disease |
| spellingShingle | L. D. Khidirova D. A. Yakhontov S. A. Zenin M. N. Mamedov Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders Рациональная фармакотерапия в кардиологии atrial fibrillation arterial hypertension diabetes mellitus obesity thyroid gland chronic obstructive pulmonary disease |
| title | Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders |
| title_full | Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders |
| title_fullStr | Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders |
| title_full_unstemmed | Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders |
| title_short | Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders |
| title_sort | features of atrial fibrillation in patients with arterial hypertension and extracardial disorders |
| topic | atrial fibrillation arterial hypertension diabetes mellitus obesity thyroid gland chronic obstructive pulmonary disease |
| url | https://www.rpcardio.online/jour/article/view/1959 |
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