Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd]
Recently, the sex determining region Y (Sry) and the cerebellar degeneration-related protein 1 (CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7,...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2014-11-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/3-90/v2 |
| _version_ | 1819048717839237120 |
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| author | Javier Tadeo Granados-Riveron Guillermo Aquino-Jarquin |
| author_facet | Javier Tadeo Granados-Riveron Guillermo Aquino-Jarquin |
| author_sort | Javier Tadeo Granados-Riveron |
| collection | DOAJ |
| description | Recently, the sex determining region Y (Sry) and the cerebellar degeneration-related protein 1 (CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the Sry gene is its ability to generate linear and circular transcripts, both transcribed in the sense orientation. Here we remark that both sense (e.g. Sry RNA) and antisense (e.g. CDR1as) transcripts could circularize and behave as miRNAs sponges, and importantly, that also protein-coding segments of mRNAs could also assume this role. Thus, it is reasonable to think that the linear Sry sense transcript could additionally act as a miRNA sponge, or as an endogenous competing RNA for miR-138. |
| first_indexed | 2024-12-21T11:20:42Z |
| format | Article |
| id | doaj.art-4e234cc3d69242cebe1ac51f1d0b6200 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T11:20:42Z |
| publishDate | 2014-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-4e234cc3d69242cebe1ac51f1d0b62002022-12-21T19:05:47ZengF1000 Research LtdF1000Research2046-14022014-11-01310.12688/f1000research.3872.26097Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd]Javier Tadeo Granados-Riveron0Guillermo Aquino-Jarquin1Laboratorio de Investigación en Genómica, Genética y Bioinformática, Hospital Infantil de México Federico Gómez, Mexico City, 06720, MexicoLaboratorio de Investigación en Genómica, Genética y Bioinformática, Hospital Infantil de México Federico Gómez, Mexico City, 06720, MexicoRecently, the sex determining region Y (Sry) and the cerebellar degeneration-related protein 1 (CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the Sry gene is its ability to generate linear and circular transcripts, both transcribed in the sense orientation. Here we remark that both sense (e.g. Sry RNA) and antisense (e.g. CDR1as) transcripts could circularize and behave as miRNAs sponges, and importantly, that also protein-coding segments of mRNAs could also assume this role. Thus, it is reasonable to think that the linear Sry sense transcript could additionally act as a miRNA sponge, or as an endogenous competing RNA for miR-138.http://f1000research.com/articles/3-90/v2GenomicsStructure: RNA |
| spellingShingle | Javier Tadeo Granados-Riveron Guillermo Aquino-Jarquin Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd] F1000Research Genomics Structure: RNA |
| title | Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd] |
| title_full | Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd] |
| title_fullStr | Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd] |
| title_full_unstemmed | Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd] |
| title_short | Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense [v2; ref status: indexed, http://f1000r.es/4pd] |
| title_sort | does the linear sry transcript function as a cerna for mir 138 the sense of antisense v2 ref status indexed http f1000r es 4pd |
| topic | Genomics Structure: RNA |
| url | http://f1000research.com/articles/3-90/v2 |
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