Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea
Objectives Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owing to the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2. Its Delta and Omicron variants are more transmissible and pathogenic than other variants. Some debates have emerged on...
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| Format: | Article |
| Language: | English |
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Korea Disease Control and Prevention Agency
2023-08-01
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| Series: | Osong Public Health and Research Perspectives |
| Subjects: | |
| Online Access: | http://ophrp.org/upload/pdf/j-phrp-2023-0024.pdf |
| _version_ | 1827824953122095104 |
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| author | Jeong-Min Kim Dongju Kim Nam-Joo Lee Sang Hee Woo Jaehee Lee Hyeokjin Lee Ae Kyung Park Jeong-Ah Kim Chae Young Lee , Il-Hwan Kim Cheon Kwon Yoo Eun-Jin Kim |
| author_facet | Jeong-Min Kim Dongju Kim Nam-Joo Lee Sang Hee Woo Jaehee Lee Hyeokjin Lee Ae Kyung Park Jeong-Ah Kim Chae Young Lee , Il-Hwan Kim Cheon Kwon Yoo Eun-Jin Kim |
| author_sort | Jeong-Min Kim |
| collection | DOAJ |
| description | Objectives Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owing to the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2. Its Delta and Omicron variants are more transmissible and pathogenic than other variants. Some debates have emerged on the mechanism of variants of concern. In the COVID-19 wave that began in December 2021, the Omicron variant, first reported in South Africa, became identifiable in most cases globally. The aim of this study was to provide data to inform effective responses to the transmission of the Omicron variant. Methods The Delta variant and the spike protein D614G mutant were compared with the Omicron variant. Viral loads from 5 days after symptom onset were compared using epidemiological data collected at the time of diagnosis. Results The Omicron variant exhibited a higher viral load than other variants, resulting in greater transmissibility within 5 days of symptom onset. Conclusion Future research should focus on vaccine efficacy against the Omicron variant and compare trends in disease severity associated with its high viral load. |
| first_indexed | 2024-03-12T02:33:40Z |
| format | Article |
| id | doaj.art-4e23e823d2de483fa213d87229d85c03 |
| institution | Directory Open Access Journal |
| issn | 2233-6052 |
| language | English |
| last_indexed | 2024-03-12T02:33:40Z |
| publishDate | 2023-08-01 |
| publisher | Korea Disease Control and Prevention Agency |
| record_format | Article |
| series | Osong Public Health and Research Perspectives |
| spelling | doaj.art-4e23e823d2de483fa213d87229d85c032023-09-05T01:42:53ZengKorea Disease Control and Prevention AgencyOsong Public Health and Research Perspectives2233-60522023-08-0114427227810.24171/j.phrp.2023.0024726Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of KoreaJeong-Min Kim0Dongju Kim1Nam-Joo Lee2Sang Hee Woo3Jaehee Lee4Hyeokjin Lee5Ae Kyung Park6Jeong-Ah Kim7Chae Young Lee8, Il-Hwan Kim9Cheon Kwon Yoo10Eun-Jin Kim11 Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of KoreaObjectives Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owing to the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2. Its Delta and Omicron variants are more transmissible and pathogenic than other variants. Some debates have emerged on the mechanism of variants of concern. In the COVID-19 wave that began in December 2021, the Omicron variant, first reported in South Africa, became identifiable in most cases globally. The aim of this study was to provide data to inform effective responses to the transmission of the Omicron variant. Methods The Delta variant and the spike protein D614G mutant were compared with the Omicron variant. Viral loads from 5 days after symptom onset were compared using epidemiological data collected at the time of diagnosis. Results The Omicron variant exhibited a higher viral load than other variants, resulting in greater transmissibility within 5 days of symptom onset. Conclusion Future research should focus on vaccine efficacy against the Omicron variant and compare trends in disease severity associated with its high viral load.http://ophrp.org/upload/pdf/j-phrp-2023-0024.pdfomicron variantsars-cov-2transmissibility |
| spellingShingle | Jeong-Min Kim Dongju Kim Nam-Joo Lee Sang Hee Woo Jaehee Lee Hyeokjin Lee Ae Kyung Park Jeong-Ah Kim Chae Young Lee , Il-Hwan Kim Cheon Kwon Yoo Eun-Jin Kim Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea Osong Public Health and Research Perspectives omicron variant sars-cov-2 transmissibility |
| title | Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea |
| title_full | Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea |
| title_fullStr | Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea |
| title_full_unstemmed | Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea |
| title_short | Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea |
| title_sort | increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 omicron variant in the republic of korea |
| topic | omicron variant sars-cov-2 transmissibility |
| url | http://ophrp.org/upload/pdf/j-phrp-2023-0024.pdf |
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