Variable Normalization of Naïve CD4+ Lymphopenia and Markers of Monocyte and T Cell Activation over the Course of Direct-Acting Anti-Viral Treatment of Chronic Hepatitis C Virus Infection

Variable Normalization of Naïve CD4+ Lymphopenia and Markers of Monocyte and T Cell Activation over the Course of Direct-Acting Anti-Viral Treatment of Chronic Hepatitis C Virus Infection

Chronic hepatitis C virus (HCV) infection is associated with naïve CD4+ T cell lymphopenia and long-standing/persistent elevation of cellular and soluble immune activation parameters, the latter heightened in the setting of HIV co-infection. The underlying mechanisms are not completely understood. H...

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Bibliographic Details
Main Authors: Ann W. N. Auma, Carey L. Shive, Lenche Kostadinova, Donald D. Anthony
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
hepatitis C virus
direct-acting antiviral
inflammation
liver fibrosis
HIV
ageing
Online Access:https://www.mdpi.com/1999-4915/14/1/50

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