New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes
The intraocular malignancies, which mostly originate from the retina and uvea, exhibit a high incidence of blindness and even death. Uveal melanoma (UM) and retinoblastoma (RB) are the most common intraocular malignancies in adults and children, respectively. The high risks of distant metastases lea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.958170/full |
| _version_ | 1798038569951952896 |
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| author | Lingwen Gu Guofeng Ma Cui Li Jing Lin Guiqiu Zhao |
| author_facet | Lingwen Gu Guofeng Ma Cui Li Jing Lin Guiqiu Zhao |
| author_sort | Lingwen Gu |
| collection | DOAJ |
| description | The intraocular malignancies, which mostly originate from the retina and uvea, exhibit a high incidence of blindness and even death. Uveal melanoma (UM) and retinoblastoma (RB) are the most common intraocular malignancies in adults and children, respectively. The high risks of distant metastases lead to an extremely poor prognosis. Nowadays, various epidemiological studies have demonstrated that diabetes is associated with the high incidence and mortality of cancers, such as liver cancer, pancreatic cancer, and bladder cancer. However, the mechanisms and interventions associated with diabetes and intraocular malignancies have not been reviewed. In this review, we have summarized the associated mechanisms between diabetes and intraocular malignancy. Diabetes mellitus is a chronic metabolic disease characterized by prolonged periods of hyperglycemia. Recent studies have reported that the abnormal glucose metabolism, insulin resistance, and the activation of the IGF/insulin-like growth factor-1 receptor (IGF-1R) signaling axis in diabetes contribute to the genesis, growth, proliferation, and metastases of intraocular malignancy. In addition, diabetic patients are more prone to suffer severe complications and poor prognosis after radiotherapy for intraocular malignancy. Based on the common pathogenesis shared by diabetes and intraocular malignancy, they may be related to interventions and treatments. Therefore, interventions targeting the abnormal glucose metabolism, insulin resistance, and IGF-1/IGF-1R signaling axis show therapeutic potentials to treat intraocular malignancy. |
| first_indexed | 2024-04-11T21:41:59Z |
| format | Article |
| id | doaj.art-4e2537e4280f4dd093c6e203fd7e8004 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T21:41:59Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4e2537e4280f4dd093c6e203fd7e80042022-12-22T04:01:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.958170958170New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetesLingwen Gu0Guofeng Ma1Cui Li2Jing Lin3Guiqiu Zhao4Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Urology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaThe intraocular malignancies, which mostly originate from the retina and uvea, exhibit a high incidence of blindness and even death. Uveal melanoma (UM) and retinoblastoma (RB) are the most common intraocular malignancies in adults and children, respectively. The high risks of distant metastases lead to an extremely poor prognosis. Nowadays, various epidemiological studies have demonstrated that diabetes is associated with the high incidence and mortality of cancers, such as liver cancer, pancreatic cancer, and bladder cancer. However, the mechanisms and interventions associated with diabetes and intraocular malignancies have not been reviewed. In this review, we have summarized the associated mechanisms between diabetes and intraocular malignancy. Diabetes mellitus is a chronic metabolic disease characterized by prolonged periods of hyperglycemia. Recent studies have reported that the abnormal glucose metabolism, insulin resistance, and the activation of the IGF/insulin-like growth factor-1 receptor (IGF-1R) signaling axis in diabetes contribute to the genesis, growth, proliferation, and metastases of intraocular malignancy. In addition, diabetic patients are more prone to suffer severe complications and poor prognosis after radiotherapy for intraocular malignancy. Based on the common pathogenesis shared by diabetes and intraocular malignancy, they may be related to interventions and treatments. Therefore, interventions targeting the abnormal glucose metabolism, insulin resistance, and IGF-1/IGF-1R signaling axis show therapeutic potentials to treat intraocular malignancy.https://www.frontiersin.org/articles/10.3389/fonc.2022.958170/fullintraocular malignancyuveal melanomaretinoblastomaWarburg effectinsulin resistanceinsulin-like growth factor-1 receptor |
| spellingShingle | Lingwen Gu Guofeng Ma Cui Li Jing Lin Guiqiu Zhao New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes Frontiers in Oncology intraocular malignancy uveal melanoma retinoblastoma Warburg effect insulin resistance insulin-like growth factor-1 receptor |
| title | New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes |
| title_full | New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes |
| title_fullStr | New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes |
| title_full_unstemmed | New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes |
| title_short | New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes |
| title_sort | new insights into the prognosis of intraocular malignancy interventions for association mechanisms between cancer and diabetes |
| topic | intraocular malignancy uveal melanoma retinoblastoma Warburg effect insulin resistance insulin-like growth factor-1 receptor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.958170/full |
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