| Summary: | Components for manufacturing polyurethane foams can adversely affect the human body, particularly if they are in contact with it for long periods. In applications where the foam is not placed directly into the body, the study of the product’s effects is often neglected. In the case of human skin, distinguishing the increasingly frequent problems of skin atopy, more attention should be paid to this. This paper presents the influence of the different catalytic systems on cytotoxic and thermomechanical properties in polyurethane foams. Among others, foams were produced with the most popular catalysts on the market, DABCO and a metal-organic tin catalyst. The foams were characterized by thermomechanical properties and were subjected to a cytotoxicity test against human keratinocytes. In biocompatibility tests with skin cells, the results were highly variable. VAB 2 with a catalytic system consisting of commercial Diethanolamine and Addocat<sup>®</sup>105 performed the best. However, with such a catalytic system, the mechanical properties have worsened.
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