Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine
Mesoporous silica nanoparticles (MSN) were synthesised and functionalised with triethylenetetramine (MSN-TETA). The samples were fully characterised (transmission electron microscopy, small angle X-ray scattering, Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potential an...
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7665 |
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| author | Cristina Carucci Nicola Scalas Andrea Porcheddu Marco Piludu Maura Monduzzi Andrea Salis |
| author_facet | Cristina Carucci Nicola Scalas Andrea Porcheddu Marco Piludu Maura Monduzzi Andrea Salis |
| author_sort | Cristina Carucci |
| collection | DOAJ |
| description | Mesoporous silica nanoparticles (MSN) were synthesised and functionalised with triethylenetetramine (MSN-TETA). The samples were fully characterised (transmission electron microscopy, small angle X-ray scattering, Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potential and nitrogen adsorption/desorption isotherms) and used as carriers for the adsorption of the antimicrobial drug sulphamethizole (SMZ). SMZ loading, quantified by UV–Vis spectroscopy, was higher on MSN-TETA (345.8 mg g<sup>−1</sup>) compared with bare MSN (215.4 mg g<sup>−1</sup>) even in the presence of a lower surface area (671 vs. 942 m<sup>2</sup> g<sup>−1</sup>). The kinetics of SMZ adsorption on MSN and MSN-TETA followed a pseudo-second-order model. The adsorption isotherm is described better by a Langmuir model rather than a Temkin or Freundlich model. Release kinetics showed a burst release of SMZ from bare MSN samples (k<sub>1</sub> = 136 h<sup>−1</sup>) in contrast to a slower release found with MSN-TETA (k<sub>1</sub> = 3.04 h<sup>−1</sup>), suggesting attractive intermolecular interactions slow down SMZ release from MSN-TETA. In summary, the MSN surface area did not influence SMZ adsorption and release. On the contrary, the design of an effective drug delivery system must consider the intermolecular interactions between the adsorbent and the adsorbate. |
| first_indexed | 2024-03-10T09:36:11Z |
| format | Article |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:11Z |
| publishDate | 2021-07-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4e285636eee648cbacf1463c3b153bb52023-11-22T04:02:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214766510.3390/ijms22147665Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with TriethylenetetramineCristina Carucci0Nicola Scalas1Andrea Porcheddu2Marco Piludu3Maura Monduzzi4Andrea Salis5Dipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria, SS 554 Bivio Sestu, 09042 Monserrato, CA, ItalyDipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria, SS 554 Bivio Sestu, 09042 Monserrato, CA, ItalyDipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria, SS 554 Bivio Sestu, 09042 Monserrato, CA, ItalyConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), via Della Lastruccia 3, 50019 Sesto Fiorentino, FI, ItalyDipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria, SS 554 Bivio Sestu, 09042 Monserrato, CA, ItalyDipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria, SS 554 Bivio Sestu, 09042 Monserrato, CA, ItalyMesoporous silica nanoparticles (MSN) were synthesised and functionalised with triethylenetetramine (MSN-TETA). The samples were fully characterised (transmission electron microscopy, small angle X-ray scattering, Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potential and nitrogen adsorption/desorption isotherms) and used as carriers for the adsorption of the antimicrobial drug sulphamethizole (SMZ). SMZ loading, quantified by UV–Vis spectroscopy, was higher on MSN-TETA (345.8 mg g<sup>−1</sup>) compared with bare MSN (215.4 mg g<sup>−1</sup>) even in the presence of a lower surface area (671 vs. 942 m<sup>2</sup> g<sup>−1</sup>). The kinetics of SMZ adsorption on MSN and MSN-TETA followed a pseudo-second-order model. The adsorption isotherm is described better by a Langmuir model rather than a Temkin or Freundlich model. Release kinetics showed a burst release of SMZ from bare MSN samples (k<sub>1</sub> = 136 h<sup>−1</sup>) in contrast to a slower release found with MSN-TETA (k<sub>1</sub> = 3.04 h<sup>−1</sup>), suggesting attractive intermolecular interactions slow down SMZ release from MSN-TETA. In summary, the MSN surface area did not influence SMZ adsorption and release. On the contrary, the design of an effective drug delivery system must consider the intermolecular interactions between the adsorbent and the adsorbate.https://www.mdpi.com/1422-0067/22/14/7665MSNantimicrobial drugadsorptionkineticsisothermsrelease |
| spellingShingle | Cristina Carucci Nicola Scalas Andrea Porcheddu Marco Piludu Maura Monduzzi Andrea Salis Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine International Journal of Molecular Sciences MSN antimicrobial drug adsorption kinetics isotherms release |
| title | Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine |
| title_full | Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine |
| title_fullStr | Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine |
| title_full_unstemmed | Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine |
| title_short | Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine |
| title_sort | adsorption and release of sulfamethizole from mesoporous silica nanoparticles functionalised with triethylenetetramine |
| topic | MSN antimicrobial drug adsorption kinetics isotherms release |
| url | https://www.mdpi.com/1422-0067/22/14/7665 |
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