THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS
Objective. 196 patients with initial reproductive loss and 123 patients with favorable outcomes of their pregnancy as a control group. The purpose of our research – to detect genetic, clinical and paraclinical risk factors for initial reproductive loss. Methods. Analysis of anamnestic data, clinic...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
The Publishing House Medicine and Enlightenment
2017-09-01
|
| Series: | Мать и дитя в Кузбассе |
| Subjects: | |
| Online Access: | http://mednauki.ru/index.php/MD/article/view/126 |
| _version_ | 1811285859418243072 |
|---|---|
| author | Екатерина Игоревна Лебедева Ольга Александровна Бельницкая Елена Станиславовна Кравцова Елена Викторовна Мегрелидзе Татьяна Ивановна Горбачева |
| author_facet | Екатерина Игоревна Лебедева Ольга Александровна Бельницкая Елена Станиславовна Кравцова Елена Викторовна Мегрелидзе Татьяна Ивановна Горбачева |
| author_sort | Екатерина Игоревна Лебедева |
| collection | DOAJ |
| description | Objective. 196 patients with initial reproductive loss and 123 patients with favorable outcomes of their pregnancy as a control group.
The purpose of our research – to detect genetic, clinical and paraclinical risk factors for initial reproductive loss.
Methods. Analysis of anamnestic data, clinical and standard lab tests results was made, in addition we evaluated hemostasiogram indices, homocysteine level, molecular genetic analysis for 4 genes coded components of hemostasis and folate cycle. Statistically significance is attained when a p-value less then 0,05.
Results. The risk factors for initial pregnancy loss was determined as somatic and gynecological burden, inherited thrombogenic risk factors such as burdened familial history in thrombophilia and arterial hypertensia, existence of arterial hypertensia, hypercoagulation syndrome, deaggregating thrombocytopathy, hyperhomocysteinemia and homozygous care of genes responsible for fibrinolysis and folate exchange, and acquired thrombogenic risk factors such as nicotine dependence and hormonal contraception.
Conclusion. Mixed somatic and gynecological pathology, abnormalities in hemostasis, combination of inherited and acquired thrombogenic risk factors dominates in women with initial reproductive loss, though only 37,3 % such pregnancies have favorable outcome. |
| first_indexed | 2024-04-13T02:50:21Z |
| format | Article |
| id | doaj.art-4e2a19eea4cf41e28b81338ce27184ac |
| institution | Directory Open Access Journal |
| issn | 1991-010X 2542-0968 |
| language | Russian |
| last_indexed | 2024-04-13T02:50:21Z |
| publishDate | 2017-09-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Мать и дитя в Кузбассе |
| spelling | doaj.art-4e2a19eea4cf41e28b81338ce27184ac2022-12-22T03:05:51ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе1991-010X2542-09682017-09-011834953114THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSSЕкатерина Игоревна Лебедева0Ольга Александровна Бельницкая1Елена Станиславовна Кравцова2Елена Викторовна Мегрелидзе3Татьяна Ивановна Горбачева4ФГБОУ ВО АГМУ Минздрава России, г. БарнаулФГБОУ ВО АГМУ Минздрава России, г. БарнаулФГБОУ ВО АГМУ Минздрава России, г. БарнаулФГБОУ ВО АГМУ Минздрава России, г. БарнаулФГБОУ ВО АГМУ Минздрава России, г. БарнаулObjective. 196 patients with initial reproductive loss and 123 patients with favorable outcomes of their pregnancy as a control group. The purpose of our research – to detect genetic, clinical and paraclinical risk factors for initial reproductive loss. Methods. Analysis of anamnestic data, clinical and standard lab tests results was made, in addition we evaluated hemostasiogram indices, homocysteine level, molecular genetic analysis for 4 genes coded components of hemostasis and folate cycle. Statistically significance is attained when a p-value less then 0,05. Results. The risk factors for initial pregnancy loss was determined as somatic and gynecological burden, inherited thrombogenic risk factors such as burdened familial history in thrombophilia and arterial hypertensia, existence of arterial hypertensia, hypercoagulation syndrome, deaggregating thrombocytopathy, hyperhomocysteinemia and homozygous care of genes responsible for fibrinolysis and folate exchange, and acquired thrombogenic risk factors such as nicotine dependence and hormonal contraception. Conclusion. Mixed somatic and gynecological pathology, abnormalities in hemostasis, combination of inherited and acquired thrombogenic risk factors dominates in women with initial reproductive loss, though only 37,3 % such pregnancies have favorable outcome.http://mednauki.ru/index.php/MD/article/view/126первичные репродуктивные потеригемостазтромбофилияфакторы тромбогенного риска |
| spellingShingle | Екатерина Игоревна Лебедева Ольга Александровна Бельницкая Елена Станиславовна Кравцова Елена Викторовна Мегрелидзе Татьяна Ивановна Горбачева THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS Мать и дитя в Кузбассе первичные репродуктивные потери гемостаз тромбофилия факторы тромбогенного риска |
| title | THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS |
| title_full | THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS |
| title_fullStr | THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS |
| title_full_unstemmed | THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS |
| title_short | THE RISK FACTORS FOR INITIAL REPRODUCTIVE LOSS |
| title_sort | risk factors for initial reproductive loss |
| topic | первичные репродуктивные потери гемостаз тромбофилия факторы тромбогенного риска |
| url | http://mednauki.ru/index.php/MD/article/view/126 |
| work_keys_str_mv | AT ekaterinaigorevnalebedeva theriskfactorsforinitialreproductiveloss AT olʹgaaleksandrovnabelʹnickaâ theriskfactorsforinitialreproductiveloss AT elenastanislavovnakravcova theriskfactorsforinitialreproductiveloss AT elenaviktorovnamegrelidze theriskfactorsforinitialreproductiveloss AT tatʹânaivanovnagorbačeva theriskfactorsforinitialreproductiveloss AT ekaterinaigorevnalebedeva riskfactorsforinitialreproductiveloss AT olʹgaaleksandrovnabelʹnickaâ riskfactorsforinitialreproductiveloss AT elenastanislavovnakravcova riskfactorsforinitialreproductiveloss AT elenaviktorovnamegrelidze riskfactorsforinitialreproductiveloss AT tatʹânaivanovnagorbačeva riskfactorsforinitialreproductiveloss |