Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19
Background Patients hospitalized with COVID‐19 have an increased risk of thromboembolic events. Whether sex, race or ethnicity impacts these events is unknown. We studied the association between sex, race, and ethnicity and venous and arterial thromboembolic events among adults hospitalized with COV...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.022829 |
| _version_ | 1797942665517465600 |
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| author | Sadia Ilyas Stanislav Henkin Pablo Martinez‐Camblor Bjoern D. Suckow Jocelyn M. Beach David H. Stone Philip P. Goodney Joseph E. Ebinger Mark A. Creager Jesse A. Columbo |
| author_facet | Sadia Ilyas Stanislav Henkin Pablo Martinez‐Camblor Bjoern D. Suckow Jocelyn M. Beach David H. Stone Philip P. Goodney Joseph E. Ebinger Mark A. Creager Jesse A. Columbo |
| author_sort | Sadia Ilyas |
| collection | DOAJ |
| description | Background Patients hospitalized with COVID‐19 have an increased risk of thromboembolic events. Whether sex, race or ethnicity impacts these events is unknown. We studied the association between sex, race, and ethnicity and venous and arterial thromboembolic events among adults hospitalized with COVID‐19. Methods and Results We used the American Heart Association Cardiovascular Disease COVID‐19 registry. Primary exposures were sex and race and ethnicity, as defined by the registry. Primary outcomes were venous thromboembolic events and arterial thromboembolic events. We used logistic regression for risk adjustment. We studied 21 528 adults hospitalized with COVID‐19 across 107 centers (54.1% men; 38.1% non‐Hispanic White, 25.4% Hispanic, 25.7% non‐Hispanic Black, 0.5% Native American, 4.0% Asian, 0.4% Pacific Islander, and 5.9% other race and ethnicity). The rate of venous thromboembolic events was 3.7% and was more common in men (4.2%) than women (3.2%; P<0.001), and in non‐Hispanic Black patients (4.9%) than other races and ethnicities (range, 1.3%–3.8%; P<0.001). The rate of arterial thromboembolic events was 3.9% and was more common in men (4.3%) than women (3.5%; P=0.002), and in non‐Hispanic Black patients (5.0%) than other races and ethnicities (range, 2.3%–4.7%; P<0.001). Compared with men, women were less likely to experience venous thromboembolic events (adjusted odds ratio [OR], 0.71; 95% CI, 0.61–0.83) and arterial thromboembolic events (adjusted OR, 0.76; 95% CI, 0.66–0.89). Compared with non‐Hispanic White patients, non‐Hispanic Black patients had the highest likelihood of venous thromboembolic events (adjusted OR, 1.27; 95% CI, 1.04–1.54) and arterial thromboembolic events (adjusted OR, 1.35; 95% CI, 1.11–1.65). Conclusions Men and non‐Hispanic Black adults hospitalized with COVID‐19 are more likely to have venous and arterial thromboembolic events. These subgroups may represent at‐risk patients more susceptible to thromboembolic COVID‐19 complications. |
| first_indexed | 2024-04-10T20:12:15Z |
| format | Article |
| id | doaj.art-4e2aeaf26ee9411999a7d04f4c020059 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T20:12:15Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-4e2aeaf26ee9411999a7d04f4c0200592023-01-26T10:36:40ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-12-01102310.1161/JAHA.121.022829Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19Sadia Ilyas0Stanislav Henkin1Pablo Martinez‐Camblor2Bjoern D. Suckow3Jocelyn M. Beach4David H. Stone5Philip P. Goodney6Joseph E. Ebinger7Mark A. Creager8Jesse A. Columbo9Section of Vascular Surgery, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Cardiovascular Medicine, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHDepartment of Anesthesiology Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Vascular Surgery, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Vascular Surgery, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Vascular Surgery, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Vascular Surgery, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Cardiovascular Medicine Smidt Heart Institute, Cedars‐Sinai Medical Center Los Angeles CASection of Cardiovascular Medicine, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHSection of Vascular Surgery, Heart and Vascular Center Dartmouth‐Hitchcock Medical Center Lebanon NHBackground Patients hospitalized with COVID‐19 have an increased risk of thromboembolic events. Whether sex, race or ethnicity impacts these events is unknown. We studied the association between sex, race, and ethnicity and venous and arterial thromboembolic events among adults hospitalized with COVID‐19. Methods and Results We used the American Heart Association Cardiovascular Disease COVID‐19 registry. Primary exposures were sex and race and ethnicity, as defined by the registry. Primary outcomes were venous thromboembolic events and arterial thromboembolic events. We used logistic regression for risk adjustment. We studied 21 528 adults hospitalized with COVID‐19 across 107 centers (54.1% men; 38.1% non‐Hispanic White, 25.4% Hispanic, 25.7% non‐Hispanic Black, 0.5% Native American, 4.0% Asian, 0.4% Pacific Islander, and 5.9% other race and ethnicity). The rate of venous thromboembolic events was 3.7% and was more common in men (4.2%) than women (3.2%; P<0.001), and in non‐Hispanic Black patients (4.9%) than other races and ethnicities (range, 1.3%–3.8%; P<0.001). The rate of arterial thromboembolic events was 3.9% and was more common in men (4.3%) than women (3.5%; P=0.002), and in non‐Hispanic Black patients (5.0%) than other races and ethnicities (range, 2.3%–4.7%; P<0.001). Compared with men, women were less likely to experience venous thromboembolic events (adjusted odds ratio [OR], 0.71; 95% CI, 0.61–0.83) and arterial thromboembolic events (adjusted OR, 0.76; 95% CI, 0.66–0.89). Compared with non‐Hispanic White patients, non‐Hispanic Black patients had the highest likelihood of venous thromboembolic events (adjusted OR, 1.27; 95% CI, 1.04–1.54) and arterial thromboembolic events (adjusted OR, 1.35; 95% CI, 1.11–1.65). Conclusions Men and non‐Hispanic Black adults hospitalized with COVID‐19 are more likely to have venous and arterial thromboembolic events. These subgroups may represent at‐risk patients more susceptible to thromboembolic COVID‐19 complications.https://www.ahajournals.org/doi/10.1161/JAHA.121.022829COVID‐19race and ethnicitythromboembolicthrombosiswomen, sex, and gender |
| spellingShingle | Sadia Ilyas Stanislav Henkin Pablo Martinez‐Camblor Bjoern D. Suckow Jocelyn M. Beach David H. Stone Philip P. Goodney Joseph E. Ebinger Mark A. Creager Jesse A. Columbo Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease COVID‐19 race and ethnicity thromboembolic thrombosis women, sex, and gender |
| title | Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19 |
| title_full | Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19 |
| title_fullStr | Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19 |
| title_full_unstemmed | Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19 |
| title_short | Sex‐, Race‐ and Ethnicity‐Based Differences in Thromboembolic Events Among Adults Hospitalized With COVID‐19 |
| title_sort | sex race and ethnicity based differences in thromboembolic events among adults hospitalized with covid 19 |
| topic | COVID‐19 race and ethnicity thromboembolic thrombosis women, sex, and gender |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.022829 |
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