Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin
These changes correlate with the development of oxidative stress in animals over the entire duration of the experiment, which manifested by an increase in the content of the lipoperoxidation products (LPO) - conjugated diene level and malonic dialdehide) in the lungs in comparison with control grou...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2017-12-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/25092 |
| _version_ | 1818247713851965440 |
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| author | Mariana Ljubomurivna Baida Oksana Volodumurivna Sadljak Stepan Mykhailovuch Reheda |
| author_facet | Mariana Ljubomurivna Baida Oksana Volodumurivna Sadljak Stepan Mykhailovuch Reheda |
| author_sort | Mariana Ljubomurivna Baida |
| collection | DOAJ |
| description |
These changes correlate with the development of oxidative stress in animals over the entire duration of the experiment, which manifested by an increase in the content of the lipoperoxidation products (LPO) - conjugated diene level and malonic dialdehide) in the lungs in comparison with control group. Decreasing of the antioxidant activity (a significant reduction of peroxidase and ceruloplazmin level) in the lung`s tissure of guinea pigs has been reported. Correction of these shifts with the antioxidant drug thiotriazolin inhibits accumulation of LPO products and increases antioxidant defense. The experimental data most probably indicate a pronounced effect of thiotriazolin on the realization of the antiinflammatory and antioxidant effects and allows a suggestion about the antiradical mechanism of this drugs.
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| first_indexed | 2024-12-12T15:09:05Z |
| format | Article |
| id | doaj.art-4e2ceb6c0f6f4dd9ba3c3eb1fb2efc72 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-12T15:09:05Z |
| publishDate | 2017-12-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-4e2ceb6c0f6f4dd9ba3c3eb1fb2efc722022-12-22T00:20:39ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-12-01712Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolinMariana Ljubomurivna Baida0Oksana Volodumurivna Sadljak1Stepan Mykhailovuch Reheda2Danylo Halytsky Lviv National Medical UniversityDanylo Halytsky Lviv National Medical UniversityDanylo Halytsky Lviv National Medical University These changes correlate with the development of oxidative stress in animals over the entire duration of the experiment, which manifested by an increase in the content of the lipoperoxidation products (LPO) - conjugated diene level and malonic dialdehide) in the lungs in comparison with control group. Decreasing of the antioxidant activity (a significant reduction of peroxidase and ceruloplazmin level) in the lung`s tissure of guinea pigs has been reported. Correction of these shifts with the antioxidant drug thiotriazolin inhibits accumulation of LPO products and increases antioxidant defense. The experimental data most probably indicate a pronounced effect of thiotriazolin on the realization of the antiinflammatory and antioxidant effects and allows a suggestion about the antiradical mechanism of this drugs. https://apcz.umk.pl/JEHS/article/view/25092experimental allergic alveolitisperoxide lipid oxidationantioxidant systemthiotriazolin |
| spellingShingle | Mariana Ljubomurivna Baida Oksana Volodumurivna Sadljak Stepan Mykhailovuch Reheda Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin Journal of Education, Health and Sport experimental allergic alveolitis peroxide lipid oxidation antioxidant system thiotriazolin |
| title | Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin |
| title_full | Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin |
| title_fullStr | Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin |
| title_full_unstemmed | Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin |
| title_short | Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin |
| title_sort | changes in activity of some indicators of pro oxidant and antioxidant systems in guinea pigs lungs in experimental allergic alveolitis and their correction with thiotriazolin |
| topic | experimental allergic alveolitis peroxide lipid oxidation antioxidant system thiotriazolin |
| url | https://apcz.umk.pl/JEHS/article/view/25092 |
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