The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319305894 |
| _version_ | 1818193096020590592 |
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| author | Yukio Ago Ryota Araki Koji Yano Toshiyuki Kawasaki Shigeyuki Chaki Atsuro Nakazato Hirotaka Onoe Hitoshi Hashimoto Akemichi Baba Kazuhiro Takuma Toshio Matsuda |
| author_facet | Yukio Ago Ryota Araki Koji Yano Toshiyuki Kawasaki Shigeyuki Chaki Atsuro Nakazato Hirotaka Onoe Hitoshi Hashimoto Akemichi Baba Kazuhiro Takuma Toshio Matsuda |
| author_sort | Yukio Ago |
| collection | DOAJ |
| description | Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reared mice. MGS0028 attenuated hyperactivity and aggressive behaviors in isolation-reared mice. The agonist also reversed isolation rearing–induced deficits of prepulse inhibition. On the other hand, MGS0028 did not affect locomotor activity and prepulse inhibition in group-reared mice. These results suggest that the metabotropic glutamate 2/3 receptor agonist, MGS0028, is a potential compound for the treatment of psychiatric disorders. Keywords:: metabotropic glutamate 2/3 receptor, isolation rearing, behavior |
| first_indexed | 2024-12-12T00:40:57Z |
| format | Article |
| id | doaj.art-4e2d714e64ac47989531a1512ba36cf8 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-12T00:40:57Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-4e2d714e64ac47989531a1512ba36cf82022-12-22T00:44:15ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011182295298The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in MiceYukio Ago0Ryota Araki1Koji Yano2Toshiyuki Kawasaki3Shigeyuki Chaki4Atsuro Nakazato5Hirotaka Onoe6Hitoshi Hashimoto7Akemichi Baba8Kazuhiro Takuma9Toshio Matsuda10Laboratory of Medicinal Pharmacology, 1-6 Yamada-oka, Suita, Osaka 565-0871, JapanLaboratory of Medicinal Pharmacology, 1-6 Yamada-oka, Suita, Osaka 565-0871, JapanLaboratory of Medicinal Pharmacology, 1-6 Yamada-oka, Suita, Osaka 565-0871, JapanFunctional Probe Research Laboratory, RIKEN, Center for Molecular Imaging Science, Kobe MI R&D Center, C6-7-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, JapanMolecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, JapanStrategic Planning of Drug Discovery, R&D Headquarters of Pharmaceutical Operation, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, JapanFunctional Probe Research Laboratory, RIKEN, Center for Molecular Imaging Science, Kobe MI R&D Center, C6-7-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, JapanLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan; Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, JapanLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan; Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe, Hyogo 650-8530, JapanLaboratory of Medicinal Pharmacology, 1-6 Yamada-oka, Suita, Osaka 565-0871, JapanLaboratory of Medicinal Pharmacology, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan; Corresponding author. matsuda@phs.osaka-u.ac.jpIsolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reared mice. MGS0028 attenuated hyperactivity and aggressive behaviors in isolation-reared mice. The agonist also reversed isolation rearing–induced deficits of prepulse inhibition. On the other hand, MGS0028 did not affect locomotor activity and prepulse inhibition in group-reared mice. These results suggest that the metabotropic glutamate 2/3 receptor agonist, MGS0028, is a potential compound for the treatment of psychiatric disorders. Keywords:: metabotropic glutamate 2/3 receptor, isolation rearing, behaviorhttp://www.sciencedirect.com/science/article/pii/S1347861319305894 |
| spellingShingle | Yukio Ago Ryota Araki Koji Yano Toshiyuki Kawasaki Shigeyuki Chaki Atsuro Nakazato Hirotaka Onoe Hitoshi Hashimoto Akemichi Baba Kazuhiro Takuma Toshio Matsuda The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice Journal of Pharmacological Sciences |
| title | The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice |
| title_full | The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice |
| title_fullStr | The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice |
| title_full_unstemmed | The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice |
| title_short | The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice |
| title_sort | selective metabotropic glutamate 2 3 receptor agonist mgs0028 reverses isolation rearing induced abnormal behaviors in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319305894 |
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