Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders
The neurophysiological mechanisms underlying motor and language difficulties in autism spectrum disorders (ASD) are still largely unclear. The present work investigates biological indicators of sound processing, (action-) semantic understanding and predictive coding and their correlation with clinic...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00395/full |
| _version_ | 1818976456014823424 |
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| author | Luigi Grisoni Rachel L. Moseley Shiva Motlagh Dimitra Kandia Dimitra Kandia Neslihan Sener Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller Stefan Roepke Bettina Mohr Bettina Mohr |
| author_facet | Luigi Grisoni Rachel L. Moseley Shiva Motlagh Dimitra Kandia Dimitra Kandia Neslihan Sener Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller Stefan Roepke Bettina Mohr Bettina Mohr |
| author_sort | Luigi Grisoni |
| collection | DOAJ |
| description | The neurophysiological mechanisms underlying motor and language difficulties in autism spectrum disorders (ASD) are still largely unclear. The present work investigates biological indicators of sound processing, (action-) semantic understanding and predictive coding and their correlation with clinical symptoms of ASD. Twenty-two adults with high-functioning ASD and 25 typically developed (TD) participants engaged in an auditory, passive listening, Mismatch Negativity (MMN) task while high-density electroencephalography (EEG) was recorded. Action and non-action words were presented in the context of sounds, which were either semantically congruent with regard to the body part they relate to or semantically incongruent or unrelated. The anticipatory activity before sound onset, the Prediction Potential (PP), was significantly reduced in the ASD group specifically for action, but not for non-action sounds. The early-MMN-like responses to words (latency: 120 ms) were differentially modulated across groups: controls showed larger amplitudes for words in action-sound compared to non-action contexts, whereas ASD participants demonstrated enlarged early-MMN-like responses only in a pure tone context, with no other modulation dependent on action sound context. Late-MMN-like responses around 560 ms post-stimulus onset revealed body-part-congruent action-semantic priming for words in control participants, but not in the ASD group. Importantly, neurophysiological indices of semantic priming in ASD participants correlated with the extent of autistic traits as revealed by the Autism Spectrum Quotient (AQ). The data suggest that high-functioning adults with ASD show a specific deficit in semantic processing and predictive coding of sounds and words related to action, which is absent for neutral, non-action, sounds. |
| first_indexed | 2024-12-20T16:12:08Z |
| format | Article |
| id | doaj.art-4e2f0d62c79149bd9d403fe25316608f |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-20T16:12:08Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-4e2f0d62c79149bd9d403fe25316608f2022-12-21T19:33:56ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-11-011310.3389/fnhum.2019.00395465044Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum DisordersLuigi Grisoni0Rachel L. Moseley1Shiva Motlagh2Dimitra Kandia3Dimitra Kandia4Neslihan Sener5Friedemann Pulvermüller6Friedemann Pulvermüller7Friedemann Pulvermüller8Stefan Roepke9Bettina Mohr10Bettina Mohr11Brain Language Laboratory, Department of Philosophy and Humanities, Freie Universität Berlin, Berlin, GermanyDepartment of Psychology, University of Bournemouth, Poole, United KingdomBerlin School of Mind and Brain, Humboldt Universität zu Berlin, Berlin, GermanyBrain Language Laboratory, Department of Philosophy and Humanities, Freie Universität Berlin, Berlin, GermanyDepartment of Neurology, Max Planck Institute for Human and Brain Sciences, Leipzig, GermanyBrain Language Laboratory, Department of Philosophy and Humanities, Freie Universität Berlin, Berlin, GermanyBrain Language Laboratory, Department of Philosophy and Humanities, Freie Universität Berlin, Berlin, GermanyBerlin School of Mind and Brain, Humboldt Universität zu Berlin, Berlin, GermanyEinstein Center for Neurosciences, Berlin, GermanyDepartment of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, GermanyDepartment of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, GermanyZentrum für Neuropsychologie und Intensive Sprachtherapie (ZeNIS), Berlin, GermanyThe neurophysiological mechanisms underlying motor and language difficulties in autism spectrum disorders (ASD) are still largely unclear. The present work investigates biological indicators of sound processing, (action-) semantic understanding and predictive coding and their correlation with clinical symptoms of ASD. Twenty-two adults with high-functioning ASD and 25 typically developed (TD) participants engaged in an auditory, passive listening, Mismatch Negativity (MMN) task while high-density electroencephalography (EEG) was recorded. Action and non-action words were presented in the context of sounds, which were either semantically congruent with regard to the body part they relate to or semantically incongruent or unrelated. The anticipatory activity before sound onset, the Prediction Potential (PP), was significantly reduced in the ASD group specifically for action, but not for non-action sounds. The early-MMN-like responses to words (latency: 120 ms) were differentially modulated across groups: controls showed larger amplitudes for words in action-sound compared to non-action contexts, whereas ASD participants demonstrated enlarged early-MMN-like responses only in a pure tone context, with no other modulation dependent on action sound context. Late-MMN-like responses around 560 ms post-stimulus onset revealed body-part-congruent action-semantic priming for words in control participants, but not in the ASD group. Importantly, neurophysiological indices of semantic priming in ASD participants correlated with the extent of autistic traits as revealed by the Autism Spectrum Quotient (AQ). The data suggest that high-functioning adults with ASD show a specific deficit in semantic processing and predictive coding of sounds and words related to action, which is absent for neutral, non-action, sounds.https://www.frontiersin.org/article/10.3389/fnhum.2019.00395/fullautism spectrum disordersprediction potentialmismatch negativitygrounded cognitionevent-related potentials |
| spellingShingle | Luigi Grisoni Rachel L. Moseley Shiva Motlagh Dimitra Kandia Dimitra Kandia Neslihan Sener Friedemann Pulvermüller Friedemann Pulvermüller Friedemann Pulvermüller Stefan Roepke Bettina Mohr Bettina Mohr Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders Frontiers in Human Neuroscience autism spectrum disorders prediction potential mismatch negativity grounded cognition event-related potentials |
| title | Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders |
| title_full | Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders |
| title_fullStr | Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders |
| title_full_unstemmed | Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders |
| title_short | Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders |
| title_sort | prediction and mismatch negativity responses reflect impairments in action semantic processing in adults with autism spectrum disorders |
| topic | autism spectrum disorders prediction potential mismatch negativity grounded cognition event-related potentials |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00395/full |
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