Cell Line Platforms Support Research into Arthropod Immunity
Innate immune responses are essential to maintaining insect and tick health and are the primary defense against pathogenic viruses, bacteria, and fungi. Cell line research is a powerful method for understanding how invertebrates mount defenses against pathogenic organisms and testing hypotheses on h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Insects |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4450/12/8/738 |
| _version_ | 1797523427715710976 |
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| author | Cynthia L. Goodman David S. Kang David Stanley |
| author_facet | Cynthia L. Goodman David S. Kang David Stanley |
| author_sort | Cynthia L. Goodman |
| collection | DOAJ |
| description | Innate immune responses are essential to maintaining insect and tick health and are the primary defense against pathogenic viruses, bacteria, and fungi. Cell line research is a powerful method for understanding how invertebrates mount defenses against pathogenic organisms and testing hypotheses on how these responses occur. In particular, immortal arthropod cell lines are valuable tools, providing a tractable, high-throughput, cost-effective, and consistent platform to investigate the mechanisms underpinning insect and tick immune responses. The research results inform the controls of medically and agriculturally important insects and ticks. This review presents several examples of how cell lines have facilitated research into multiple aspects of the invertebrate immune response to pathogens and other foreign agents, as well as comments on possible future research directions in these robust systems. |
| first_indexed | 2024-03-10T08:42:48Z |
| format | Article |
| id | doaj.art-4e2fc63f9ba744139b4f960d5fc4e079 |
| institution | Directory Open Access Journal |
| issn | 2075-4450 |
| language | English |
| last_indexed | 2024-03-10T08:42:48Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj.art-4e2fc63f9ba744139b4f960d5fc4e0792023-11-22T08:07:50ZengMDPI AGInsects2075-44502021-08-0112873810.3390/insects12080738Cell Line Platforms Support Research into Arthropod ImmunityCynthia L. Goodman0David S. Kang1David Stanley2Biological Control of Insects Research Laboratory, USDA/Agricultural Research Service, 1503 S. Providence Rd., Columbia, MO 65203, USABiological Control of Insects Research Laboratory, USDA/Agricultural Research Service, 1503 S. Providence Rd., Columbia, MO 65203, USABiological Control of Insects Research Laboratory, USDA/Agricultural Research Service, 1503 S. Providence Rd., Columbia, MO 65203, USAInnate immune responses are essential to maintaining insect and tick health and are the primary defense against pathogenic viruses, bacteria, and fungi. Cell line research is a powerful method for understanding how invertebrates mount defenses against pathogenic organisms and testing hypotheses on how these responses occur. In particular, immortal arthropod cell lines are valuable tools, providing a tractable, high-throughput, cost-effective, and consistent platform to investigate the mechanisms underpinning insect and tick immune responses. The research results inform the controls of medically and agriculturally important insects and ticks. This review presents several examples of how cell lines have facilitated research into multiple aspects of the invertebrate immune response to pathogens and other foreign agents, as well as comments on possible future research directions in these robust systems.https://www.mdpi.com/2075-4450/12/8/738innate immunityantimicrobial peptideRNAilysozymepathogensignaling pathway |
| spellingShingle | Cynthia L. Goodman David S. Kang David Stanley Cell Line Platforms Support Research into Arthropod Immunity Insects innate immunity antimicrobial peptide RNAi lysozyme pathogen signaling pathway |
| title | Cell Line Platforms Support Research into Arthropod Immunity |
| title_full | Cell Line Platforms Support Research into Arthropod Immunity |
| title_fullStr | Cell Line Platforms Support Research into Arthropod Immunity |
| title_full_unstemmed | Cell Line Platforms Support Research into Arthropod Immunity |
| title_short | Cell Line Platforms Support Research into Arthropod Immunity |
| title_sort | cell line platforms support research into arthropod immunity |
| topic | innate immunity antimicrobial peptide RNAi lysozyme pathogen signaling pathway |
| url | https://www.mdpi.com/2075-4450/12/8/738 |
| work_keys_str_mv | AT cynthialgoodman celllineplatformssupportresearchintoarthropodimmunity AT davidskang celllineplatformssupportresearchintoarthropodimmunity AT davidstanley celllineplatformssupportresearchintoarthropodimmunity |