MiRNA-mediated EMT and CSCs in cancer chemoresistance
Abstract Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-021-00206-5 |
| _version_ | 1819048644590960640 |
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| author | Bing Dong Shiyu Li Shuangli Zhu Ming Yi Suxia Luo Kongming Wu |
| author_facet | Bing Dong Shiyu Li Shuangli Zhu Ming Yi Suxia Luo Kongming Wu |
| author_sort | Bing Dong |
| collection | DOAJ |
| description | Abstract Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be driven by EMT. In this complex process, microRNAs (miRNAs) are found to play a key role. In order to overcome the drug resistance, inhibiting EMT as well as CSCs phenotype seem feasible. Thereinto, regulating the EMT- or CSCs-associated miRNAs is a crucial approach. Herein, we conduct this review to elaborate on the complicated interplay between EMT and CSCs in cancer chemoresistance, which is modulated by miRNAs. In addition, we elucidate the therapeutic strategy to overcome drug resistance through targeting EMT and CSCs. |
| first_indexed | 2024-12-21T11:19:32Z |
| format | Article |
| id | doaj.art-4e30a9c2afdf4cc68815670e667487ff |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-21T11:19:32Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-4e30a9c2afdf4cc68815670e667487ff2022-12-21T19:05:49ZengBMCExperimental Hematology & Oncology2162-36192021-02-0110111210.1186/s40164-021-00206-5MiRNA-mediated EMT and CSCs in cancer chemoresistanceBing Dong0Shiyu Li1Shuangli Zhu2Ming Yi3Suxia Luo4Kongming Wu5Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyAbstract Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be driven by EMT. In this complex process, microRNAs (miRNAs) are found to play a key role. In order to overcome the drug resistance, inhibiting EMT as well as CSCs phenotype seem feasible. Thereinto, regulating the EMT- or CSCs-associated miRNAs is a crucial approach. Herein, we conduct this review to elaborate on the complicated interplay between EMT and CSCs in cancer chemoresistance, which is modulated by miRNAs. In addition, we elucidate the therapeutic strategy to overcome drug resistance through targeting EMT and CSCs.https://doi.org/10.1186/s40164-021-00206-5miRNAEMTCSCsChemoresistance |
| spellingShingle | Bing Dong Shiyu Li Shuangli Zhu Ming Yi Suxia Luo Kongming Wu MiRNA-mediated EMT and CSCs in cancer chemoresistance Experimental Hematology & Oncology miRNA EMT CSCs Chemoresistance |
| title | MiRNA-mediated EMT and CSCs in cancer chemoresistance |
| title_full | MiRNA-mediated EMT and CSCs in cancer chemoresistance |
| title_fullStr | MiRNA-mediated EMT and CSCs in cancer chemoresistance |
| title_full_unstemmed | MiRNA-mediated EMT and CSCs in cancer chemoresistance |
| title_short | MiRNA-mediated EMT and CSCs in cancer chemoresistance |
| title_sort | mirna mediated emt and cscs in cancer chemoresistance |
| topic | miRNA EMT CSCs Chemoresistance |
| url | https://doi.org/10.1186/s40164-021-00206-5 |
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