Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment
Abstract This study aimed to investigate the cortical microstructural/macrostructural degenerative patterns in Parkinson’s disease (PD) patients with mild cognitive impairment (MCI). Overall, 38 PD patients with normal cognition (PD-NC), 38 PD-MCI, and 32 healthy controls (HC) were included. PD-MCI...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-022-00416-6 |
| _version_ | 1827775462261129216 |
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| author | Xueqin Bai Tao Guo Jingwen Chen Xiaojun Guan Cheng Zhou Jingjing Wu Xiaocao Liu Haoting Wu Jiaqi Wen Luyan Gu Ting Gao Min Xuan Peiyu Huang Baorong Zhang Xiaojun Xu Minming Zhang |
| author_facet | Xueqin Bai Tao Guo Jingwen Chen Xiaojun Guan Cheng Zhou Jingjing Wu Xiaocao Liu Haoting Wu Jiaqi Wen Luyan Gu Ting Gao Min Xuan Peiyu Huang Baorong Zhang Xiaojun Xu Minming Zhang |
| author_sort | Xueqin Bai |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the cortical microstructural/macrostructural degenerative patterns in Parkinson’s disease (PD) patients with mild cognitive impairment (MCI). Overall, 38 PD patients with normal cognition (PD-NC), 38 PD-MCI, and 32 healthy controls (HC) were included. PD-MCI was diagnosed according to the MDS Task Force level II criteria. Cortical microstructural alterations were evaluated with Neurite Orientation Dispersion and Density Imaging. Cortical thickness analyses were derived from T1-weighted imaging using the FreeSurfer software. For cortical microstructural analyses, compared with HC, PD-NC showed lower orientation dispersion index (ODI) in bilateral cingulate and paracingulate gyri, supplementary motor area, right paracentral lobule, and precuneus (P FWE < 0.05); while PD-MCI showed lower ODI in widespread regions covering bilateral frontal, parietal, occipital, and right temporal areas and lower neurite density index in left frontal area, left cingulate, and paracingulate gyri (P FWE < 0.05). Furthermore, compared with PD-NC, PD-MCI showed reduced ODI in right frontal area and bilateral caudate nuclei (voxel P < 0.01 and cluster >100 voxels) and the ODI values were associated with the Montreal Cognitive Assessment scores (r = 0.440, P < 0.001) and the memory performance (r = 0.333, P = 0.004) in the PD patients. However, for cortical thickness analyses, there was no difference in the between-group comparisons. In conclusion, cortical microstructural alterations may precede macrostructural changes in PD-MCI. This study provides insightful evidence for the degenerative patterns in PD-MCI and contributes to our understanding of the latent biological basis of cortical neurite changes for early cognitive impairment in PD. |
| first_indexed | 2024-03-11T13:51:07Z |
| format | Article |
| id | doaj.art-4e30e61d7038462c9191df8844a1f79c |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:51:07Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-4e30e61d7038462c9191df8844a1f79c2023-11-02T08:41:30ZengNature Portfolionpj Parkinson's Disease2373-80572022-11-01811910.1038/s41531-022-00416-6Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairmentXueqin Bai0Tao Guo1Jingwen Chen2Xiaojun Guan3Cheng Zhou4Jingjing Wu5Xiaocao Liu6Haoting Wu7Jiaqi Wen8Luyan Gu9Ting Gao10Min Xuan11Peiyu Huang12Baorong Zhang13Xiaojun Xu14Minming Zhang15Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineAbstract This study aimed to investigate the cortical microstructural/macrostructural degenerative patterns in Parkinson’s disease (PD) patients with mild cognitive impairment (MCI). Overall, 38 PD patients with normal cognition (PD-NC), 38 PD-MCI, and 32 healthy controls (HC) were included. PD-MCI was diagnosed according to the MDS Task Force level II criteria. Cortical microstructural alterations were evaluated with Neurite Orientation Dispersion and Density Imaging. Cortical thickness analyses were derived from T1-weighted imaging using the FreeSurfer software. For cortical microstructural analyses, compared with HC, PD-NC showed lower orientation dispersion index (ODI) in bilateral cingulate and paracingulate gyri, supplementary motor area, right paracentral lobule, and precuneus (P FWE < 0.05); while PD-MCI showed lower ODI in widespread regions covering bilateral frontal, parietal, occipital, and right temporal areas and lower neurite density index in left frontal area, left cingulate, and paracingulate gyri (P FWE < 0.05). Furthermore, compared with PD-NC, PD-MCI showed reduced ODI in right frontal area and bilateral caudate nuclei (voxel P < 0.01 and cluster >100 voxels) and the ODI values were associated with the Montreal Cognitive Assessment scores (r = 0.440, P < 0.001) and the memory performance (r = 0.333, P = 0.004) in the PD patients. However, for cortical thickness analyses, there was no difference in the between-group comparisons. In conclusion, cortical microstructural alterations may precede macrostructural changes in PD-MCI. This study provides insightful evidence for the degenerative patterns in PD-MCI and contributes to our understanding of the latent biological basis of cortical neurite changes for early cognitive impairment in PD.https://doi.org/10.1038/s41531-022-00416-6 |
| spellingShingle | Xueqin Bai Tao Guo Jingwen Chen Xiaojun Guan Cheng Zhou Jingjing Wu Xiaocao Liu Haoting Wu Jiaqi Wen Luyan Gu Ting Gao Min Xuan Peiyu Huang Baorong Zhang Xiaojun Xu Minming Zhang Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment npj Parkinson's Disease |
| title | Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment |
| title_full | Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment |
| title_fullStr | Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment |
| title_full_unstemmed | Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment |
| title_short | Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment |
| title_sort | microstructural but not macrostructural cortical degeneration occurs in parkinson s disease with mild cognitive impairment |
| url | https://doi.org/10.1038/s41531-022-00416-6 |
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