The oral-gut-circulatory axis: from homeostasis to colon cancer
The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1289452/full |
| _version_ | 1827766617836093440 |
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| author | Sofia C. Tortora Maria Gonzalez Agurto Laura A. Martello |
| author_facet | Sofia C. Tortora Maria Gonzalez Agurto Laura A. Martello |
| author_sort | Sofia C. Tortora |
| collection | DOAJ |
| description | The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer. |
| first_indexed | 2024-03-11T11:44:30Z |
| format | Article |
| id | doaj.art-4e31f9ead6c44bc08fef1b71ce59f292 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T11:44:30Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-4e31f9ead6c44bc08fef1b71ce59f2922023-11-09T15:20:31ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-11-011310.3389/fcimb.2023.12894521289452The oral-gut-circulatory axis: from homeostasis to colon cancerSofia C. Tortora0Maria Gonzalez Agurto1Laura A. Martello2Department of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, Brooklyn, NY, United StatesDepartamento de Rehabilitación Craneofacial Integral, Universidad de Los Andes, Santiago, ChileDepartment of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, Brooklyn, NY, United StatesThe human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1289452/fullmicrobiotaimmune responsedysbiosisoral-gut axiscirculationcolon cancer |
| spellingShingle | Sofia C. Tortora Maria Gonzalez Agurto Laura A. Martello The oral-gut-circulatory axis: from homeostasis to colon cancer Frontiers in Cellular and Infection Microbiology microbiota immune response dysbiosis oral-gut axis circulation colon cancer |
| title | The oral-gut-circulatory axis: from homeostasis to colon cancer |
| title_full | The oral-gut-circulatory axis: from homeostasis to colon cancer |
| title_fullStr | The oral-gut-circulatory axis: from homeostasis to colon cancer |
| title_full_unstemmed | The oral-gut-circulatory axis: from homeostasis to colon cancer |
| title_short | The oral-gut-circulatory axis: from homeostasis to colon cancer |
| title_sort | oral gut circulatory axis from homeostasis to colon cancer |
| topic | microbiota immune response dysbiosis oral-gut axis circulation colon cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1289452/full |
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