Zebrafish: A Pharmacological Model for Learning and Memory Research
Learning and memory are essential to organism survival and are conserved across various species, especially vertebrates. Cognitive studies involving learning and memory require using appropriate model organisms to translate relevant findings to humans. Zebrafish are becoming increasingly popular as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/21/7374 |
| _version_ | 1797467096068653056 |
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| author | Jen Kit Tan Faris Hazwan Nazar Suzana Makpol Seong Lin Teoh |
| author_facet | Jen Kit Tan Faris Hazwan Nazar Suzana Makpol Seong Lin Teoh |
| author_sort | Jen Kit Tan |
| collection | DOAJ |
| description | Learning and memory are essential to organism survival and are conserved across various species, especially vertebrates. Cognitive studies involving learning and memory require using appropriate model organisms to translate relevant findings to humans. Zebrafish are becoming increasingly popular as one of the animal models for neurodegenerative diseases due to their low maintenance cost, prolific nature and amenability to genetic manipulation. More importantly, zebrafish exhibit a repertoire of neurobehaviors comparable to humans. In this review, we discuss the forms of learning and memory abilities in zebrafish and the tests used to evaluate the neurobehaviors in this species. In addition, the pharmacological studies that used zebrafish as models to screen for the effects of neuroprotective and neurotoxic compounds on cognitive performance will be summarized here. Lastly, we discuss the challenges and perspectives in establishing zebrafish as a robust model for cognitive research involving learning and memory. Zebrafish are becoming an indispensable model in learning and memory research for screening neuroprotective agents against cognitive impairment. |
| first_indexed | 2024-03-09T18:47:51Z |
| format | Article |
| id | doaj.art-4e32d2195167429b840b49661cdacc27 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:47:51Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4e32d2195167429b840b49661cdacc272023-11-24T06:03:10ZengMDPI AGMolecules1420-30492022-10-012721737410.3390/molecules27217374Zebrafish: A Pharmacological Model for Learning and Memory ResearchJen Kit Tan0Faris Hazwan Nazar1Suzana Makpol2Seong Lin Teoh3Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), UKM Medical Center, Kuala Lumpur 56000, MalaysiaDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), UKM Medical Center, Kuala Lumpur 56000, MalaysiaDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), UKM Medical Center, Kuala Lumpur 56000, MalaysiaDepartment of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), UKM Medical Center, Kuala Lumpur 56000, MalaysiaLearning and memory are essential to organism survival and are conserved across various species, especially vertebrates. Cognitive studies involving learning and memory require using appropriate model organisms to translate relevant findings to humans. Zebrafish are becoming increasingly popular as one of the animal models for neurodegenerative diseases due to their low maintenance cost, prolific nature and amenability to genetic manipulation. More importantly, zebrafish exhibit a repertoire of neurobehaviors comparable to humans. In this review, we discuss the forms of learning and memory abilities in zebrafish and the tests used to evaluate the neurobehaviors in this species. In addition, the pharmacological studies that used zebrafish as models to screen for the effects of neuroprotective and neurotoxic compounds on cognitive performance will be summarized here. Lastly, we discuss the challenges and perspectives in establishing zebrafish as a robust model for cognitive research involving learning and memory. Zebrafish are becoming an indispensable model in learning and memory research for screening neuroprotective agents against cognitive impairment.https://www.mdpi.com/1420-3049/27/21/7374zebrafishpharmacological modeldrug screeninglearning and memory |
| spellingShingle | Jen Kit Tan Faris Hazwan Nazar Suzana Makpol Seong Lin Teoh Zebrafish: A Pharmacological Model for Learning and Memory Research Molecules zebrafish pharmacological model drug screening learning and memory |
| title | Zebrafish: A Pharmacological Model for Learning and Memory Research |
| title_full | Zebrafish: A Pharmacological Model for Learning and Memory Research |
| title_fullStr | Zebrafish: A Pharmacological Model for Learning and Memory Research |
| title_full_unstemmed | Zebrafish: A Pharmacological Model for Learning and Memory Research |
| title_short | Zebrafish: A Pharmacological Model for Learning and Memory Research |
| title_sort | zebrafish a pharmacological model for learning and memory research |
| topic | zebrafish pharmacological model drug screening learning and memory |
| url | https://www.mdpi.com/1420-3049/27/21/7374 |
| work_keys_str_mv | AT jenkittan zebrafishapharmacologicalmodelforlearningandmemoryresearch AT farishazwannazar zebrafishapharmacologicalmodelforlearningandmemoryresearch AT suzanamakpol zebrafishapharmacologicalmodelforlearningandmemoryresearch AT seonglinteoh zebrafishapharmacologicalmodelforlearningandmemoryresearch |