Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism
BackgroundPrimary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrena...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1061704/full |
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| author | Yi-Yao Chang Yi-Yao Chang Bo-Ching Lee Zheng-Wei Chen Cheng-Hsuan Tsai Chin-Chen Chang Che-Wei Liao Chien-Ting Pan Kang-Yung Peng Chia-Hung Chou Ching-Chu Lu Vin-Cent Wu Chi-Sheng Hung Chi-Sheng Hung Yen-Hung Lin Yen-Hung Lin TAIPAI study group |
| author_facet | Yi-Yao Chang Yi-Yao Chang Bo-Ching Lee Zheng-Wei Chen Cheng-Hsuan Tsai Chin-Chen Chang Che-Wei Liao Chien-Ting Pan Kang-Yung Peng Chia-Hung Chou Ching-Chu Lu Vin-Cent Wu Chi-Sheng Hung Chi-Sheng Hung Yen-Hung Lin Yen-Hung Lin TAIPAI study group |
| author_sort | Yi-Yao Chang |
| collection | DOAJ |
| description | BackgroundPrimary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrenalectomy. Somatic mutations are the main pathogenesis of aldosterone overproduction in APA, of which KCNJ5 somatic mutations are most common, especially in Asian countries. This article aimed to review the literature on the impacts of KCNJ5 somatic mutations on systemic organ damage.Evidence acquisitionPubMed literature research using keywords combination, including “aldosterone-producing adenoma,” “somatic mutations,” “KCNJ5,” “organ damage,” “cardiovascular,” “diastolic function,” “metabolic syndrome,” “autonomous cortisol secretion,” etc.ResultsAPA patients with KCNJ5 somatic mutations are generally younger, female, have higher aldosterone levels, lower potassium levels, larger tumor size, and higher hypertension cure rate after adrenalectomy. This review focuses on the cardiovascular and metabolic aspects of KCNJ5 somatic mutations in APA patients, including left ventricular remodeling and diastolic function, abdominal aortic thickness and calcification, arterial stiffness, metabolic syndrome, abdominal adipose tissue, and correlation with autonomous cortisol secretion. Furthermore, we discuss modalities to differentiate the types of mutations before surgery.ConclusionKCNJ5 somatic mutations in patients with APA had higher left ventricular mass (LVM), more impaired diastolic function, thicker aortic wall, lower incidence of metabolic syndrome, and possibly a lower incidence of concurrent autonomous cortisol secretion, but better improvement in LVM, diastolic function, arterial stiffness, and aortic wall thickness after adrenalectomy compared to patients without KCNJ5 mutations. |
| first_indexed | 2024-04-10T05:43:03Z |
| format | Article |
| id | doaj.art-4e34468f6a0543e190c2253ebdcc1de9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T05:43:03Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4e34468f6a0543e190c2253ebdcc1de92023-03-06T06:15:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.10617041061704Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronismYi-Yao Chang0Yi-Yao Chang1Bo-Ching Lee2Zheng-Wei Chen3Cheng-Hsuan Tsai4Chin-Chen Chang5Che-Wei Liao6Chien-Ting Pan7Kang-Yung Peng8Chia-Hung Chou9Ching-Chu Lu10Vin-Cent Wu11Chi-Sheng Hung12Chi-Sheng Hung13Yen-Hung Lin14Yen-Hung Lin15TAIPAI study groupCardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, TaiwanGraduate Institute of Medicine, Yuan Ze University, Taoyuan, TaiwanDepartment of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Medicine, National Taiwan University Cancer Center, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, TaiwanDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan0Cardiovascular Center, National Taiwan University Hospital, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan0Cardiovascular Center, National Taiwan University Hospital, Taipei, TaiwanBackgroundPrimary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrenalectomy. Somatic mutations are the main pathogenesis of aldosterone overproduction in APA, of which KCNJ5 somatic mutations are most common, especially in Asian countries. This article aimed to review the literature on the impacts of KCNJ5 somatic mutations on systemic organ damage.Evidence acquisitionPubMed literature research using keywords combination, including “aldosterone-producing adenoma,” “somatic mutations,” “KCNJ5,” “organ damage,” “cardiovascular,” “diastolic function,” “metabolic syndrome,” “autonomous cortisol secretion,” etc.ResultsAPA patients with KCNJ5 somatic mutations are generally younger, female, have higher aldosterone levels, lower potassium levels, larger tumor size, and higher hypertension cure rate after adrenalectomy. This review focuses on the cardiovascular and metabolic aspects of KCNJ5 somatic mutations in APA patients, including left ventricular remodeling and diastolic function, abdominal aortic thickness and calcification, arterial stiffness, metabolic syndrome, abdominal adipose tissue, and correlation with autonomous cortisol secretion. Furthermore, we discuss modalities to differentiate the types of mutations before surgery.ConclusionKCNJ5 somatic mutations in patients with APA had higher left ventricular mass (LVM), more impaired diastolic function, thicker aortic wall, lower incidence of metabolic syndrome, and possibly a lower incidence of concurrent autonomous cortisol secretion, but better improvement in LVM, diastolic function, arterial stiffness, and aortic wall thickness after adrenalectomy compared to patients without KCNJ5 mutations.https://www.frontiersin.org/articles/10.3389/fendo.2023.1061704/fullsomatic mutationKCNJ5autonomous cortisol secretion (ACS)adrenocortical adenomacardiovascular systemmetabolic syndrome |
| spellingShingle | Yi-Yao Chang Yi-Yao Chang Bo-Ching Lee Zheng-Wei Chen Cheng-Hsuan Tsai Chin-Chen Chang Che-Wei Liao Chien-Ting Pan Kang-Yung Peng Chia-Hung Chou Ching-Chu Lu Vin-Cent Wu Chi-Sheng Hung Chi-Sheng Hung Yen-Hung Lin Yen-Hung Lin TAIPAI study group Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism Frontiers in Endocrinology somatic mutation KCNJ5 autonomous cortisol secretion (ACS) adrenocortical adenoma cardiovascular system metabolic syndrome |
| title | Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism |
| title_full | Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism |
| title_fullStr | Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism |
| title_full_unstemmed | Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism |
| title_short | Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism |
| title_sort | cardiovascular and metabolic characters of kcnj5 somatic mutations in primary aldosteronism |
| topic | somatic mutation KCNJ5 autonomous cortisol secretion (ACS) adrenocortical adenoma cardiovascular system metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1061704/full |
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