Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism

Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism

BackgroundPrimary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrena...

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Main Authors: Yi-Yao Chang, Bo-Ching Lee, Zheng-Wei Chen, Cheng-Hsuan Tsai, Chin-Chen Chang, Che-Wei Liao, Chien-Ting Pan, Kang-Yung Peng, Chia-Hung Chou, Ching-Chu Lu, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin, TAIPAI study group
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
somatic mutation
KCNJ5
autonomous cortisol secretion (ACS)
adrenocortical adenoma
cardiovascular system
metabolic syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1061704/full

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