Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer
Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most standard treatments fail to completely eradicate GSCs, causing the recurrence of the disease. GSCs could represent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/4602 |
| _version_ | 1797504619445747712 |
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| author | Silvia Mara Baez Rodriguez Georgiana-Adeline Staicu Ani-Simona Sevastre Carina Baloi Vasile Ciubotaru Anica Dricu Ligia Gabriela Tataranu |
| author_facet | Silvia Mara Baez Rodriguez Georgiana-Adeline Staicu Ani-Simona Sevastre Carina Baloi Vasile Ciubotaru Anica Dricu Ligia Gabriela Tataranu |
| author_sort | Silvia Mara Baez Rodriguez |
| collection | DOAJ |
| description | Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most standard treatments fail to completely eradicate GSCs, causing the recurrence of the disease. GSCs could represent one reason for the low efficacy of cancer therapy and for the short relapse time. Nonetheless, experimental data suggest that the presence of therapy-resistant GSCs could explain tumor recurrence. Therefore, to effectively target GSCs, a comprehensive understanding of their biology and the survival and developing mechanisms during treatment is mandatory. This review provides an overview of the molecular features, microenvironment, detection, and targeting strategies of GSCs, an essential information required for an efficient therapy. Despite the outstanding results in oncology, researchers are still developing novel strategies, of which one could be targeting the GSCs present in the hypoxic regions and invasive edge of the glioblastoma. |
| first_indexed | 2024-03-10T04:07:08Z |
| format | Article |
| id | doaj.art-4e361c602ef4401ca5a88595dffe2466 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:07:08Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4e361c602ef4401ca5a88595dffe24662023-11-23T08:19:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239460210.3390/ijms23094602Glioblastoma Stem Cells—Useful Tools in the Battle against CancerSilvia Mara Baez Rodriguez0Georgiana-Adeline Staicu1Ani-Simona Sevastre2Carina Baloi3Vasile Ciubotaru4Anica Dricu5Ligia Gabriela Tataranu6Neurosurgical Department, Clinical Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaDepartment of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, RomaniaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Medicine and Pharmacy, 200349 Craiova, RomaniaDepartment of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, RomaniaNeurosurgical Department, Clinical Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaDepartment of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, RomaniaNeurosurgical Department, Clinical Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaGlioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most standard treatments fail to completely eradicate GSCs, causing the recurrence of the disease. GSCs could represent one reason for the low efficacy of cancer therapy and for the short relapse time. Nonetheless, experimental data suggest that the presence of therapy-resistant GSCs could explain tumor recurrence. Therefore, to effectively target GSCs, a comprehensive understanding of their biology and the survival and developing mechanisms during treatment is mandatory. This review provides an overview of the molecular features, microenvironment, detection, and targeting strategies of GSCs, an essential information required for an efficient therapy. Despite the outstanding results in oncology, researchers are still developing novel strategies, of which one could be targeting the GSCs present in the hypoxic regions and invasive edge of the glioblastoma.https://www.mdpi.com/1422-0067/23/9/4602glioblastomastem cellgrowth factorsignaling pathway |
| spellingShingle | Silvia Mara Baez Rodriguez Georgiana-Adeline Staicu Ani-Simona Sevastre Carina Baloi Vasile Ciubotaru Anica Dricu Ligia Gabriela Tataranu Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer International Journal of Molecular Sciences glioblastoma stem cell growth factor signaling pathway |
| title | Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer |
| title_full | Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer |
| title_fullStr | Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer |
| title_full_unstemmed | Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer |
| title_short | Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer |
| title_sort | glioblastoma stem cells useful tools in the battle against cancer |
| topic | glioblastoma stem cell growth factor signaling pathway |
| url | https://www.mdpi.com/1422-0067/23/9/4602 |
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