Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
Understanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss ¬¬displays intriguing similarities in some cellular responses of cochlear sensory cells such a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00276/full |
| _version_ | 1818854750966251520 |
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| author | Chao-Hui eYang Chao-Hui eYang Thomas eSchrepfer Jochen eSchacht |
| author_facet | Chao-Hui eYang Chao-Hui eYang Thomas eSchrepfer Jochen eSchacht |
| author_sort | Chao-Hui eYang |
| collection | DOAJ |
| description | Understanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss ¬¬displays intriguing similarities in some cellular responses of cochlear sensory cells such as a potential involvement of reactive oxygen species and apoptotic and necrotic cell death. On the other hand, detailed studies have revealed that molecular pathways are considerably complex and, importantly, it has become clear that pharmacological protection successful against one form of hearing loss will not necessarily protect against another. This review will summarize pathological and pathophysiological features of age-related hearing impairment (ARHI) in human and animal models and address selected aspects of the commonality (or lack thereof) of cellular responses in ARHI to drugs and noise. |
| first_indexed | 2024-12-19T07:57:41Z |
| format | Article |
| id | doaj.art-4e36aeb8b8c1407e9a53a5ab886878d4 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-19T07:57:41Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-4e36aeb8b8c1407e9a53a5ab886878d42022-12-21T20:29:57ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-07-01910.3389/fncel.2015.00276132506Age-related Hearing Impairment and the Triad of Acquired Hearing LossChao-Hui eYang0Chao-Hui eYang1Thomas eSchrepfer2Jochen eSchacht3University of MichiganKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineUniversity of MichiganUniversity of MichiganUnderstanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss ¬¬displays intriguing similarities in some cellular responses of cochlear sensory cells such as a potential involvement of reactive oxygen species and apoptotic and necrotic cell death. On the other hand, detailed studies have revealed that molecular pathways are considerably complex and, importantly, it has become clear that pharmacological protection successful against one form of hearing loss will not necessarily protect against another. This review will summarize pathological and pathophysiological features of age-related hearing impairment (ARHI) in human and animal models and address selected aspects of the commonality (or lack thereof) of cellular responses in ARHI to drugs and noise.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00276/fullPresbycusisototoxicityaminoglycoside antibioticsAcquired hearing lossNoise trauma |
| spellingShingle | Chao-Hui eYang Chao-Hui eYang Thomas eSchrepfer Jochen eSchacht Age-related Hearing Impairment and the Triad of Acquired Hearing Loss Frontiers in Cellular Neuroscience Presbycusis ototoxicity aminoglycoside antibiotics Acquired hearing loss Noise trauma |
| title | Age-related Hearing Impairment and the Triad of Acquired Hearing Loss |
| title_full | Age-related Hearing Impairment and the Triad of Acquired Hearing Loss |
| title_fullStr | Age-related Hearing Impairment and the Triad of Acquired Hearing Loss |
| title_full_unstemmed | Age-related Hearing Impairment and the Triad of Acquired Hearing Loss |
| title_short | Age-related Hearing Impairment and the Triad of Acquired Hearing Loss |
| title_sort | age related hearing impairment and the triad of acquired hearing loss |
| topic | Presbycusis ototoxicity aminoglycoside antibiotics Acquired hearing loss Noise trauma |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00276/full |
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