Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia
Recently, <i>in-vitro</i> studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for <i>in-vivo</i> culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Henc...
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MDPI AG
2021-08-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/21/16/5545 |
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| author | Izaz Raouf Piotr Gas Heung Soo Kim |
| author_facet | Izaz Raouf Piotr Gas Heung Soo Kim |
| author_sort | Izaz Raouf |
| collection | DOAJ |
| description | Recently, <i>in-vitro</i> studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for <i>in-vivo</i> culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Hence, numerical studies play a crucial role in evaluating the thermal behavior of ferrofluids. As a result, the optimum therapeutic conditions can be achieved. The presented research work aims to develop a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the <i>in-vitro</i> model using optimization through linear response theory (LRT). For that purpose, the ferrofluid solution is evaluated based on various parameters, and the temperature distribution of the system is estimated in space and time. Consequently, the optimum conditions for the ferrofluid preparation are estimated based on experimental and mathematical findings. The reliability of the presented model is evaluated via the correlation analysis between magnetic and calorimetric methods for the specific loss power (SLP) and intrinsic loss power (ILP) calculations. Besides, the presented numerical model is verified with our experimental setup. In summary, the proposed model offers a novel approach to investigate the thermal diffusion of a non-adiabatic ferrofluid sample intended for MNP hyperthermia in cancer treatment. |
| first_indexed | 2024-03-10T08:24:19Z |
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| id | doaj.art-4e37578284284a1b948c6c240de90ae4 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T08:24:19Z |
| publishDate | 2021-08-01 |
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| spelling | doaj.art-4e37578284284a1b948c6c240de90ae42023-11-22T09:41:37ZengMDPI AGSensors1424-82202021-08-012116554510.3390/s21165545Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle HyperthermiaIzaz Raouf0Piotr Gas1Heung Soo Kim2Department of Mechanical, Robotics and Energy Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715, KoreaDepartment of Electrical and Power Engineering, AGH University of Science and Technology, Mickiewicza 30 Avenue, 30-059 Krakow, PolandDepartment of Mechanical, Robotics and Energy Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715, KoreaRecently, <i>in-vitro</i> studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for <i>in-vivo</i> culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Hence, numerical studies play a crucial role in evaluating the thermal behavior of ferrofluids. As a result, the optimum therapeutic conditions can be achieved. The presented research work aims to develop a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the <i>in-vitro</i> model using optimization through linear response theory (LRT). For that purpose, the ferrofluid solution is evaluated based on various parameters, and the temperature distribution of the system is estimated in space and time. Consequently, the optimum conditions for the ferrofluid preparation are estimated based on experimental and mathematical findings. The reliability of the presented model is evaluated via the correlation analysis between magnetic and calorimetric methods for the specific loss power (SLP) and intrinsic loss power (ILP) calculations. Besides, the presented numerical model is verified with our experimental setup. In summary, the proposed model offers a novel approach to investigate the thermal diffusion of a non-adiabatic ferrofluid sample intended for MNP hyperthermia in cancer treatment.https://www.mdpi.com/1424-8220/21/16/5545cancer therapymagnetic hyperthermiamagnetic nanoparticleslinear response theoryferrofluid parametersinduction heating |
| spellingShingle | Izaz Raouf Piotr Gas Heung Soo Kim Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia Sensors cancer therapy magnetic hyperthermia magnetic nanoparticles linear response theory ferrofluid parameters induction heating |
| title | Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia |
| title_full | Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia |
| title_fullStr | Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia |
| title_full_unstemmed | Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia |
| title_short | Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia |
| title_sort | numerical investigation of ferrofluid preparation during in vitro culture of cancer therapy for magnetic nanoparticle hyperthermia |
| topic | cancer therapy magnetic hyperthermia magnetic nanoparticles linear response theory ferrofluid parameters induction heating |
| url | https://www.mdpi.com/1424-8220/21/16/5545 |
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