Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities
Epidemiological studies have demonstrated an association between bipolar disorder (BP) and endocrine diseases. Further, circadian rhythm disruptions may be a potential common pathophysiological mechanism of both disorders. This review provides a brief overview of the molecular mechanisms of circadia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1065754/full |
| _version_ | 1797960346363756544 |
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| author | Xiu Yan Peiwei Xu Xueli Sun |
| author_facet | Xiu Yan Peiwei Xu Xueli Sun |
| author_sort | Xiu Yan |
| collection | DOAJ |
| description | Epidemiological studies have demonstrated an association between bipolar disorder (BP) and endocrine diseases. Further, circadian rhythm disruptions may be a potential common pathophysiological mechanism of both disorders. This review provides a brief overview of the molecular mechanisms of circadian rhythms, as well as roles circadian rhythms play in BP and common endocrine comorbidities such as diabetes and thyroid disease. Treatments targeting the circadian system, both pharmacological and non-pharmacological, are also discussed. The hope is to elicit new interest to the importance of circadian system in BP and offer new entry points and impetus to the development of medicine. |
| first_indexed | 2024-04-11T00:45:37Z |
| format | Article |
| id | doaj.art-4e399aae78814928b7d90d5fc86d9c78 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T00:45:37Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-4e399aae78814928b7d90d5fc86d9c782023-01-05T17:24:28ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011310.3389/fpsyt.2022.10657541065754Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbiditiesXiu YanPeiwei XuXueli SunEpidemiological studies have demonstrated an association between bipolar disorder (BP) and endocrine diseases. Further, circadian rhythm disruptions may be a potential common pathophysiological mechanism of both disorders. This review provides a brief overview of the molecular mechanisms of circadian rhythms, as well as roles circadian rhythms play in BP and common endocrine comorbidities such as diabetes and thyroid disease. Treatments targeting the circadian system, both pharmacological and non-pharmacological, are also discussed. The hope is to elicit new interest to the importance of circadian system in BP and offer new entry points and impetus to the development of medicine.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1065754/fullcircadian rhythmbipolar disorderendocrine comorbiditiesclock genechronotherapy |
| spellingShingle | Xiu Yan Peiwei Xu Xueli Sun Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities Frontiers in Psychiatry circadian rhythm bipolar disorder endocrine comorbidities clock gene chronotherapy |
| title | Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities |
| title_full | Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities |
| title_fullStr | Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities |
| title_full_unstemmed | Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities |
| title_short | Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities |
| title_sort | circadian rhythm disruptions a possible link of bipolar disorder and endocrine comorbidities |
| topic | circadian rhythm bipolar disorder endocrine comorbidities clock gene chronotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1065754/full |
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