Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note
Abstract Objectives Infantile spasm (IS) is an epileptic encephalopathy with ongoing neurological damage due to seizures and epileptiform abnormalities. Epilepsy surgery is considered for children refractory to drug therapy, especially when there is a focal brain lesion. In this study, we investigat...
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Wiley
2023-10-01
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| coleção: | Brain and Behavior |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1002/brb3.3184 |
| _version_ | 1827794486827155456 |
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| author | Xinghua Xu Qun Wang Yining Zhao Xin Xu Zhichao Gan Shiyu Zhang Xiaolei Chen |
| author_facet | Xinghua Xu Qun Wang Yining Zhao Xin Xu Zhichao Gan Shiyu Zhang Xiaolei Chen |
| author_sort | Xinghua Xu |
| collection | DOAJ |
| description | Abstract Objectives Infantile spasm (IS) is an epileptic encephalopathy with ongoing neurological damage due to seizures and epileptiform abnormalities. Epilepsy surgery is considered for children refractory to drug therapy, especially when there is a focal brain lesion. In this study, we investigated the feasibility and efficacy of intraventricular stereotactic electroencephalography (SEEG) and laser ablation for the treatment of IS children with focal brain lesions. Methods We performed the first reported study using ventriculoscopic laser ablation to treat IS. Seven IS children with drug‐resistant epilepsy and definite encephalomalacia on brain magnetic resonance imaging scan were included in this study. Ablation was performed after confirmation of epileptiform discharges by SEEG under the surveillance of ventriculoscope. Results The median follow‐up time for the cohort was 3.1 years and 86% (6/7) of the children had an Engel class ≤III epilepsy at the final follow‐up. Five (71%) children had a reduction in seizure medication usage, and the other two were on the same amount as preablation. None of the children experienced serious new neurological deficits. Laser ablation might result in seizure freedom by destroying the local brain network and blocking the spread of abnormal discharges. Conclusions Intraventricular SEEG and laser ablation was feasible and effective for the treatment of IS. Further studies are warranted. |
| first_indexed | 2024-03-11T18:34:52Z |
| format | Article |
| id | doaj.art-4e3a56949c7b4b37a97e87b51d017a57 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-11T18:34:52Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-4e3a56949c7b4b37a97e87b51d017a572023-10-13T04:20:53ZengWileyBrain and Behavior2162-32792023-10-011310n/an/a10.1002/brb3.3184Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical noteXinghua Xu0Qun Wang1Yining Zhao2Xin Xu3Zhichao Gan4Shiyu Zhang5Xiaolei Chen6Department of Neurosurgery The First Medical Center of Chinese PLA General Hospital BeijingChinaDepartment of Neurosurgery The First Medical Center of Chinese PLA General Hospital BeijingChinaDepartment of Neurosurgery Erlangen‐Nuremberg University Hospital ErlangenGermanyDepartment of Neurosurgery The First Medical Center of Chinese PLA General Hospital BeijingChinaDepartment of Neurosurgery The First Medical Center of Chinese PLA General Hospital BeijingChinaDepartment of Neurosurgery The First Medical Center of Chinese PLA General Hospital BeijingChinaDepartment of Neurosurgery The First Medical Center of Chinese PLA General Hospital BeijingChinaAbstract Objectives Infantile spasm (IS) is an epileptic encephalopathy with ongoing neurological damage due to seizures and epileptiform abnormalities. Epilepsy surgery is considered for children refractory to drug therapy, especially when there is a focal brain lesion. In this study, we investigated the feasibility and efficacy of intraventricular stereotactic electroencephalography (SEEG) and laser ablation for the treatment of IS children with focal brain lesions. Methods We performed the first reported study using ventriculoscopic laser ablation to treat IS. Seven IS children with drug‐resistant epilepsy and definite encephalomalacia on brain magnetic resonance imaging scan were included in this study. Ablation was performed after confirmation of epileptiform discharges by SEEG under the surveillance of ventriculoscope. Results The median follow‐up time for the cohort was 3.1 years and 86% (6/7) of the children had an Engel class ≤III epilepsy at the final follow‐up. Five (71%) children had a reduction in seizure medication usage, and the other two were on the same amount as preablation. None of the children experienced serious new neurological deficits. Laser ablation might result in seizure freedom by destroying the local brain network and blocking the spread of abnormal discharges. Conclusions Intraventricular SEEG and laser ablation was feasible and effective for the treatment of IS. Further studies are warranted.https://doi.org/10.1002/brb3.3184epilepsyinfantile spasmlaser ablationventriculoscope |
| spellingShingle | Xinghua Xu Qun Wang Yining Zhao Xin Xu Zhichao Gan Shiyu Zhang Xiaolei Chen Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note Brain and Behavior epilepsy infantile spasm laser ablation ventriculoscope |
| title | Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note |
| title_full | Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note |
| title_fullStr | Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note |
| title_full_unstemmed | Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note |
| title_short | Intraventricular SEEG and laser ablation for the treatment of infantile spasm: Technical note |
| title_sort | intraventricular seeg and laser ablation for the treatment of infantile spasm technical note |
| topic | epilepsy infantile spasm laser ablation ventriculoscope |
| url | https://doi.org/10.1002/brb3.3184 |
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