The Functional Role of Long Non-Coding RNAs in Melanoma
Melanoma is the most lethal skin cancer, with increasing incidence worldwide. The molecular events that drive melanoma development and progression have been extensively studied, resulting in significant improvements in diagnostics and therapeutic approaches. However, a high drug resistance to target...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4848 |
| _version_ | 1797516714763616256 |
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| author | Michal Wozniak Malgorzata Czyz |
| author_facet | Michal Wozniak Malgorzata Czyz |
| author_sort | Michal Wozniak |
| collection | DOAJ |
| description | Melanoma is the most lethal skin cancer, with increasing incidence worldwide. The molecular events that drive melanoma development and progression have been extensively studied, resulting in significant improvements in diagnostics and therapeutic approaches. However, a high drug resistance to targeted therapies and adverse effects of immunotherapies are still a major challenge in melanoma treatment. Therefore, the elucidation of molecular mechanisms of melanomagenesis and cancer response to treatment is of great importance. Recently, many studies have revealed the close association of long noncoding RNAs (lncRNAs) with the development of many cancers, including melanoma. These RNA molecules are able to regulate a plethora of crucial cellular processes including proliferation, differentiation, migration, invasion and apoptosis through diverse mechanisms, and even slight dysregulation of their expression may lead to tumorigenesis. lncRNAs are able to bind to protein complexes, DNA and RNAs, affecting their stability, activity, and localization. They can also regulate gene expression in the nucleus. Several functions of lncRNAs are context-dependent. This review summarizes current knowledge regarding the involvement of lncRNAs in melanoma. Their possible role as prognostic markers of melanoma response to treatment and in resistance to therapy is also discussed |
| first_indexed | 2024-03-10T07:04:43Z |
| format | Article |
| id | doaj.art-4e3c027cf1774e9ea5f91a614d8496a3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:04:43Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4e3c027cf1774e9ea5f91a614d8496a32023-11-22T15:53:14ZengMDPI AGCancers2072-66942021-09-011319484810.3390/cancers13194848The Functional Role of Long Non-Coding RNAs in MelanomaMichal Wozniak0Malgorzata Czyz1Department of Molecular Biology of Cancer, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Molecular Biology of Cancer, Medical University of Lodz, 92-215 Lodz, PolandMelanoma is the most lethal skin cancer, with increasing incidence worldwide. The molecular events that drive melanoma development and progression have been extensively studied, resulting in significant improvements in diagnostics and therapeutic approaches. However, a high drug resistance to targeted therapies and adverse effects of immunotherapies are still a major challenge in melanoma treatment. Therefore, the elucidation of molecular mechanisms of melanomagenesis and cancer response to treatment is of great importance. Recently, many studies have revealed the close association of long noncoding RNAs (lncRNAs) with the development of many cancers, including melanoma. These RNA molecules are able to regulate a plethora of crucial cellular processes including proliferation, differentiation, migration, invasion and apoptosis through diverse mechanisms, and even slight dysregulation of their expression may lead to tumorigenesis. lncRNAs are able to bind to protein complexes, DNA and RNAs, affecting their stability, activity, and localization. They can also regulate gene expression in the nucleus. Several functions of lncRNAs are context-dependent. This review summarizes current knowledge regarding the involvement of lncRNAs in melanoma. Their possible role as prognostic markers of melanoma response to treatment and in resistance to therapy is also discussedhttps://www.mdpi.com/2072-6694/13/19/4848melanomalncRNAdrug resistancetargeted therapyoncogenestumor suppressors |
| spellingShingle | Michal Wozniak Malgorzata Czyz The Functional Role of Long Non-Coding RNAs in Melanoma Cancers melanoma lncRNA drug resistance targeted therapy oncogenes tumor suppressors |
| title | The Functional Role of Long Non-Coding RNAs in Melanoma |
| title_full | The Functional Role of Long Non-Coding RNAs in Melanoma |
| title_fullStr | The Functional Role of Long Non-Coding RNAs in Melanoma |
| title_full_unstemmed | The Functional Role of Long Non-Coding RNAs in Melanoma |
| title_short | The Functional Role of Long Non-Coding RNAs in Melanoma |
| title_sort | functional role of long non coding rnas in melanoma |
| topic | melanoma lncRNA drug resistance targeted therapy oncogenes tumor suppressors |
| url | https://www.mdpi.com/2072-6694/13/19/4848 |
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