Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?
Venous thromboembolism (VTE), a common condition in Western countries, is a cardiovascular disorder that arises due to haemostatic irregularities, which lead to thrombus generation inside veins. Even with successful treatment, the resulting disease spectrum of complications considerably affects the...
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MDPI AG
2023-07-01
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author | Inês Soares Marques Valéria Tavares Beatriz Vieira Neto Inês N. R. Mota Deolinda Pereira Rui Medeiros |
author_facet | Inês Soares Marques Valéria Tavares Beatriz Vieira Neto Inês N. R. Mota Deolinda Pereira Rui Medeiros |
author_sort | Inês Soares Marques |
collection | DOAJ |
description | Venous thromboembolism (VTE), a common condition in Western countries, is a cardiovascular disorder that arises due to haemostatic irregularities, which lead to thrombus generation inside veins. Even with successful treatment, the resulting disease spectrum of complications considerably affects the patient’s quality of life, potentially leading to death. Cumulative data indicate that long non-coding RNAs (lncRNAs) may have a role in VTE pathogenesis. However, the clinical usefulness of these RNAs as biomarkers and potential therapeutic targets for VTE management is yet unclear. Thus, this article reviewed the emerging evidence on lncRNAs associated with VTE and with the activity of the coagulation system, which has a central role in disease pathogenesis. Until now, ten lncRNAs have been implicated in VTE pathogenesis, among which MALAT1 is the one with more evidence. Meanwhile, five lncRNAs have been reported to affect the expression of TFPI2, an important anticoagulant protein, but none with a described role in VTE development. More investigation in this field is needed as lncRNAs may help dissect VTE pathways, aiding in disease prediction, prevention and treatment. |
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institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-11T00:26:17Z |
publishDate | 2023-07-01 |
publisher | MDPI AG |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-4e3c6f81abf8444c9b769104ef899f612023-11-18T23:00:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124151210310.3390/ijms241512103Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?Inês Soares Marques0Valéria Tavares1Beatriz Vieira Neto2Inês N. R. Mota3Deolinda Pereira4Rui Medeiros5Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep., Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep., Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep., Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep., Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalOncology Department, Portuguese Institute of Oncology of Porto (IPOP), 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep., Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalVenous thromboembolism (VTE), a common condition in Western countries, is a cardiovascular disorder that arises due to haemostatic irregularities, which lead to thrombus generation inside veins. Even with successful treatment, the resulting disease spectrum of complications considerably affects the patient’s quality of life, potentially leading to death. Cumulative data indicate that long non-coding RNAs (lncRNAs) may have a role in VTE pathogenesis. However, the clinical usefulness of these RNAs as biomarkers and potential therapeutic targets for VTE management is yet unclear. Thus, this article reviewed the emerging evidence on lncRNAs associated with VTE and with the activity of the coagulation system, which has a central role in disease pathogenesis. Until now, ten lncRNAs have been implicated in VTE pathogenesis, among which MALAT1 is the one with more evidence. Meanwhile, five lncRNAs have been reported to affect the expression of TFPI2, an important anticoagulant protein, but none with a described role in VTE development. More investigation in this field is needed as lncRNAs may help dissect VTE pathways, aiding in disease prediction, prevention and treatment.https://www.mdpi.com/1422-0067/24/15/12103RNAlong non-codingvenous thromboembolismdeep vein thrombosistissue-factor-pathway inhibitor 2 |
spellingShingle | Inês Soares Marques Valéria Tavares Beatriz Vieira Neto Inês N. R. Mota Deolinda Pereira Rui Medeiros Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand? International Journal of Molecular Sciences RNA long non-coding venous thromboembolism deep vein thrombosis tissue-factor-pathway inhibitor 2 |
title | Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand? |
title_full | Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand? |
title_fullStr | Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand? |
title_full_unstemmed | Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand? |
title_short | Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand? |
title_sort | long non coding rnas in venous thromboembolism where do we stand |
topic | RNA long non-coding venous thromboembolism deep vein thrombosis tissue-factor-pathway inhibitor 2 |
url | https://www.mdpi.com/1422-0067/24/15/12103 |
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