Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography

ObjectiveTo assess aortic dilatation and determine its related factors in infants with coarctation of the aorta (CoA) by using computed tomography angiography (CTA).MethodsThe clinical data of 55 infantile patients with CoA diagnosed by CTA were analyzed retrospectively. Aortic diameters were measur...

Full description

Bibliographic Details
Main Authors: Hui-Jun Xiao, A-Lai Zhan, Qing-Wen Huang, Rui-Gang Huang, Wei-Hua Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1034334/full
_version_ 1797957680224010240
author Hui-Jun Xiao
A-Lai Zhan
Qing-Wen Huang
Rui-Gang Huang
Wei-Hua Lin
author_facet Hui-Jun Xiao
A-Lai Zhan
Qing-Wen Huang
Rui-Gang Huang
Wei-Hua Lin
author_sort Hui-Jun Xiao
collection DOAJ
description ObjectiveTo assess aortic dilatation and determine its related factors in infants with coarctation of the aorta (CoA) by using computed tomography angiography (CTA).MethodsThe clinical data of 55 infantile patients with CoA diagnosed by CTA were analyzed retrospectively. Aortic diameters were measured at six different levels and standardized as Z scores based on the square root of body surface area. The results of simple and complex CoA were compared. Univariate and multivariate logistic regression were used to analyze the effects of sex, age, hypertension, degree of coarctation, CoA type, bicuspid aortic valve (BAV), and other factors related to aortic dilatation.ResultsIn total, 52 infant patients with CoA were analyzed, including 22 cases of simple CoA and 30 cases of complex CoA. The ascending aorta of the infants in the simple CoA group and the complex CoA group were dilated to different degrees, but the difference was not statistically significant (50.00% vs. 73.33%, P = 0.084, and 2.05 ± 0.40 vs. 2.22 ± 0.43 P = 0.143). The infants in the complex CoA group had more aortic arch hypoplasia than those in the simple CoA group (33.33% vs. 9.09%, P = 0.042). Compared to the ventricular septal defect (VSD) group, the Z score of the ascending aorta in the CoA group was significantly higher than that in the VSD group (P = 0.023 and P = 0.000). A logistic retrospective analysis found that an increased degree of coarctation (CDR value) was an independent predictor of ascending aortic dilatation (adjusted OR = 0.002; P = 0.034).ConclusionInfants with simple or complex CoA are at risk of ascending aortic dilatation, and the factors of ascending aortic dilatation depend on the degree of coarctation. The risk of aortic dilatation in infants with CoA can be identified by CTA.
first_indexed 2024-04-11T00:07:35Z
format Article
id doaj.art-4e3d0456830c4bd39e7da17d90ba9985
institution Directory Open Access Journal
issn 2297-055X
language English
last_indexed 2024-04-11T00:07:35Z
publishDate 2023-01-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Cardiovascular Medicine
spelling doaj.art-4e3d0456830c4bd39e7da17d90ba99852023-01-09T08:41:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10343341034334Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiographyHui-Jun XiaoA-Lai ZhanQing-Wen HuangRui-Gang HuangWei-Hua LinObjectiveTo assess aortic dilatation and determine its related factors in infants with coarctation of the aorta (CoA) by using computed tomography angiography (CTA).MethodsThe clinical data of 55 infantile patients with CoA diagnosed by CTA were analyzed retrospectively. Aortic diameters were measured at six different levels and standardized as Z scores based on the square root of body surface area. The results of simple and complex CoA were compared. Univariate and multivariate logistic regression were used to analyze the effects of sex, age, hypertension, degree of coarctation, CoA type, bicuspid aortic valve (BAV), and other factors related to aortic dilatation.ResultsIn total, 52 infant patients with CoA were analyzed, including 22 cases of simple CoA and 30 cases of complex CoA. The ascending aorta of the infants in the simple CoA group and the complex CoA group were dilated to different degrees, but the difference was not statistically significant (50.00% vs. 73.33%, P = 0.084, and 2.05 ± 0.40 vs. 2.22 ± 0.43 P = 0.143). The infants in the complex CoA group had more aortic arch hypoplasia than those in the simple CoA group (33.33% vs. 9.09%, P = 0.042). Compared to the ventricular septal defect (VSD) group, the Z score of the ascending aorta in the CoA group was significantly higher than that in the VSD group (P = 0.023 and P = 0.000). A logistic retrospective analysis found that an increased degree of coarctation (CDR value) was an independent predictor of ascending aortic dilatation (adjusted OR = 0.002; P = 0.034).ConclusionInfants with simple or complex CoA are at risk of ascending aortic dilatation, and the factors of ascending aortic dilatation depend on the degree of coarctation. The risk of aortic dilatation in infants with CoA can be identified by CTA.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1034334/fullCTACoAdiagnosisaortic dilatationinfant
spellingShingle Hui-Jun Xiao
A-Lai Zhan
Qing-Wen Huang
Rui-Gang Huang
Wei-Hua Lin
Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography
Frontiers in Cardiovascular Medicine
CTA
CoA
diagnosis
aortic dilatation
infant
title Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography
title_full Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography
title_fullStr Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography
title_full_unstemmed Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography
title_short Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography
title_sort evaluation of the aorta in infants with simple or complex coarctation of the aorta using ct angiography
topic CTA
CoA
diagnosis
aortic dilatation
infant
url https://www.frontiersin.org/articles/10.3389/fcvm.2022.1034334/full
work_keys_str_mv AT huijunxiao evaluationoftheaortaininfantswithsimpleorcomplexcoarctationoftheaortausingctangiography
AT alaizhan evaluationoftheaortaininfantswithsimpleorcomplexcoarctationoftheaortausingctangiography
AT qingwenhuang evaluationoftheaortaininfantswithsimpleorcomplexcoarctationoftheaortausingctangiography
AT ruiganghuang evaluationoftheaortaininfantswithsimpleorcomplexcoarctationoftheaortausingctangiography
AT weihualin evaluationoftheaortaininfantswithsimpleorcomplexcoarctationoftheaortausingctangiography