Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study
Purpose: To evaluate the clinical utility of percentage of serum prostate-specific antigen (proPSA) to free PSA (%p2PSA) and the prostate health index (PHI) for predicting aggressive pathological outcomes of radical prostatectomy (RP) in Korean males. Materials and Methods: This prospective observat...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2020-01-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-42.pdf |
| _version_ | 1828397014146088960 |
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| author | Hongzoo Park Sang Wook Lee Geehyun Song Tae Wook Kang Jae Hung Jung Hyun Chul Chung Sung Jin Kim Jong Yeon Park Tae Young Shin Jeong Hyun Kim |
| author_facet | Hongzoo Park Sang Wook Lee Geehyun Song Tae Wook Kang Jae Hung Jung Hyun Chul Chung Sung Jin Kim Jong Yeon Park Tae Young Shin Jeong Hyun Kim |
| author_sort | Hongzoo Park |
| collection | DOAJ |
| description | Purpose: To evaluate the clinical utility of percentage of serum prostate-specific antigen (proPSA) to free PSA (%p2PSA) and the prostate health index (PHI) for predicting aggressive pathological outcomes of radical prostatectomy (RP) in Korean males. Materials and Methods: This prospective observational multicenter study included 160 Korean males who consecutively underwent RP. The predictive utility of preoperative %p2PSA and PHI for predicting the following pathological outcomes of RP including pT3 disease, pathologic Gleason sum ≥7, and Gleason sum upgrading was investigated using multivariate and decision-curve analyses. Results: The PHI and %p2PSA levels were significantly higher in patients with pT3 disease, pathologic Gleason sum ≥7, and Gleason sum upgrading. On univariate analysis, PHI was an accurate predictor of pT3 disease, pathologic Gleason sum ≥7, and Gleason sum upgrading. Multivariate and decision curve analyses revealed that inclusion of PHI to a base multivariate model including total PSA, percentage free PSA, PSA density, percentage of positive biopsy core, biopsy Gleason sum, and clinical stage factors significantly increased its predictive accuracy; %p2PSA showed a similar result. However, PHI was a more valuable predictor of pathological outcomes of RP. Conclusions: This study revealed PHI and %p2PSA as preoperative biomarkers of pathological outcomes in Korean males who underwent RP for prostate cancer. |
| first_indexed | 2024-12-10T08:39:20Z |
| format | Article |
| id | doaj.art-4e3e12af4d5548a7b42226cd9adb8eea |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-10T08:39:20Z |
| publishDate | 2020-01-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-4e3e12af4d5548a7b42226cd9adb8eea2022-12-22T01:55:54ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2020-01-01611425010.4111/icu.2020.61.1.42Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional studyHongzoo Park0Sang Wook Lee1Geehyun Song2Tae Wook Kang3Jae Hung Jung4Hyun Chul Chung5Sung Jin Kim6Jong Yeon Park7Tae Young Shin8Jeong Hyun Kim9Department of Urology, Kangwon National University School of Medicine, Chuncheon, Korea.Department of Urology, Kangwon National University School of Medicine, Chuncheon, Korea.Department of Urology, Kangwon National University School of Medicine, Chuncheon, Korea.Department of Urology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.Department of Urology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.Department of Urology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.Department of Urology, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.Department of Urology, Kangwon National University School of Medicine, Chuncheon, Korea.Purpose: To evaluate the clinical utility of percentage of serum prostate-specific antigen (proPSA) to free PSA (%p2PSA) and the prostate health index (PHI) for predicting aggressive pathological outcomes of radical prostatectomy (RP) in Korean males. Materials and Methods: This prospective observational multicenter study included 160 Korean males who consecutively underwent RP. The predictive utility of preoperative %p2PSA and PHI for predicting the following pathological outcomes of RP including pT3 disease, pathologic Gleason sum ≥7, and Gleason sum upgrading was investigated using multivariate and decision-curve analyses. Results: The PHI and %p2PSA levels were significantly higher in patients with pT3 disease, pathologic Gleason sum ≥7, and Gleason sum upgrading. On univariate analysis, PHI was an accurate predictor of pT3 disease, pathologic Gleason sum ≥7, and Gleason sum upgrading. Multivariate and decision curve analyses revealed that inclusion of PHI to a base multivariate model including total PSA, percentage free PSA, PSA density, percentage of positive biopsy core, biopsy Gleason sum, and clinical stage factors significantly increased its predictive accuracy; %p2PSA showed a similar result. However, PHI was a more valuable predictor of pathological outcomes of RP. Conclusions: This study revealed PHI and %p2PSA as preoperative biomarkers of pathological outcomes in Korean males who underwent RP for prostate cancer.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-42.pdfpathologyprostatectomyprostatic neoplasms |
| spellingShingle | Hongzoo Park Sang Wook Lee Geehyun Song Tae Wook Kang Jae Hung Jung Hyun Chul Chung Sung Jin Kim Jong Yeon Park Tae Young Shin Jeong Hyun Kim Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study Investigative and Clinical Urology pathology prostatectomy prostatic neoplasms |
| title | Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study |
| title_full | Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study |
| title_fullStr | Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study |
| title_full_unstemmed | Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study |
| title_short | Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study |
| title_sort | preoperative prostate health index and p2psa as the significant biomarkers of postoperative pathological outcomes of prostate cancer in korean males a prospective multi institutional study |
| topic | pathology prostatectomy prostatic neoplasms |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-42.pdf |
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