Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada
Abstract Objectives To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs). Methods An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 a...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-022-02843-5 |
| _version_ | 1818545957461032960 |
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| author | Naizhuo Zhao Audrey Smargiassi Sonia Jean Philippe Gamache Elhadji-Anassour Laouan-Sidi Hong Chen Mark S. Goldberg Sasha Bernatsky |
| author_facet | Naizhuo Zhao Audrey Smargiassi Sonia Jean Philippe Gamache Elhadji-Anassour Laouan-Sidi Hong Chen Mark S. Goldberg Sasha Bernatsky |
| author_sort | Naizhuo Zhao |
| collection | DOAJ |
| description | Abstract Objectives To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs). Methods An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 and 2013. We defined incident SARD cases (SLE, Sjogren’s syndrome, scleroderma, polymyositis, dermatomyositis, polyarteritis nodosa and related conditions, polymyalgia rheumatic, other necrotizing vasculopathies, and undifferentiated connective tissue disease) based on at least two relevant billing diagnostic codes (within 2 years, with at least 1 billing from a rheumatologist), or at least one relevant hospitalization diagnostic code. Estimated PM2.5 and ozone concentrations (derived from remote sensing and/or chemical transport models) were assigned to subjects based on residential postal codes, updated throughout follow-up. Cox proportional hazards models with annual exposure levels were used to calculate hazard ratios (HRs) for SARDs incidence, adjusting for sex, age, urban-versus-rural residence, and socioeconomic status. Results The adjusted HR for SARDS related to one interquartile range increase in PM2.5 (3.97 µg/m3) was 1.12 (95% confidence interval 1.08–1.15), but there was no clear association with ozone. Indirectly controlling for smoking did not alter the findings. Conclusions We found associations between SARDs incidence and PM2.5, but no relationships with ozone. Additional studies are needed to better understand interplays between the many constituents of air pollution and rheumatic diseases. |
| first_indexed | 2024-12-12T07:46:45Z |
| format | Article |
| id | doaj.art-4e3e7d79bc2b4e26befd8902bc4ecf6d |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-12T07:46:45Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-4e3e7d79bc2b4e26befd8902bc4ecf6d2022-12-22T00:32:35ZengBMCArthritis Research & Therapy1478-63622022-06-012411610.1186/s13075-022-02843-5Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, CanadaNaizhuo Zhao0Audrey Smargiassi1Sonia Jean2Philippe Gamache3Elhadji-Anassour Laouan-Sidi4Hong Chen5Mark S. Goldberg6Sasha Bernatsky7Division of Clinical Epidemiology, McGill University Health CentreDépartement de Santé Environnementale Et de Santé Au Travail, School of Public Health, Université de MontréalCentre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L’Île-de-MontréalCentre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L’Île-de-MontréalCentre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L’Île-de-MontréalEnvironmental Health Science and Research Bureau, Health CanadaDivision of Clinical Epidemiology, McGill University Health CentreDivision of Clinical Epidemiology, McGill University Health CentreAbstract Objectives To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs). Methods An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 and 2013. We defined incident SARD cases (SLE, Sjogren’s syndrome, scleroderma, polymyositis, dermatomyositis, polyarteritis nodosa and related conditions, polymyalgia rheumatic, other necrotizing vasculopathies, and undifferentiated connective tissue disease) based on at least two relevant billing diagnostic codes (within 2 years, with at least 1 billing from a rheumatologist), or at least one relevant hospitalization diagnostic code. Estimated PM2.5 and ozone concentrations (derived from remote sensing and/or chemical transport models) were assigned to subjects based on residential postal codes, updated throughout follow-up. Cox proportional hazards models with annual exposure levels were used to calculate hazard ratios (HRs) for SARDs incidence, adjusting for sex, age, urban-versus-rural residence, and socioeconomic status. Results The adjusted HR for SARDS related to one interquartile range increase in PM2.5 (3.97 µg/m3) was 1.12 (95% confidence interval 1.08–1.15), but there was no clear association with ozone. Indirectly controlling for smoking did not alter the findings. Conclusions We found associations between SARDs incidence and PM2.5, but no relationships with ozone. Additional studies are needed to better understand interplays between the many constituents of air pollution and rheumatic diseases.https://doi.org/10.1186/s13075-022-02843-5Systemic autoimmune rheumatic diseasesAir pollutionFine particulate matterOzone |
| spellingShingle | Naizhuo Zhao Audrey Smargiassi Sonia Jean Philippe Gamache Elhadji-Anassour Laouan-Sidi Hong Chen Mark S. Goldberg Sasha Bernatsky Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada Arthritis Research & Therapy Systemic autoimmune rheumatic diseases Air pollution Fine particulate matter Ozone |
| title | Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada |
| title_full | Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada |
| title_fullStr | Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada |
| title_full_unstemmed | Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada |
| title_short | Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada |
| title_sort | long term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases an open cohort study in quebec canada |
| topic | Systemic autoimmune rheumatic diseases Air pollution Fine particulate matter Ozone |
| url | https://doi.org/10.1186/s13075-022-02843-5 |
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