Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome
Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These poly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1285411/full |
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| author | Selorm Philip Segbefia Selorm Philip Segbefia Diana Asema Asandem Diana Asema Asandem Linda Eva Amoah Linda Eva Amoah Kwadwo Asamoah Kusi Kwadwo Asamoah Kusi |
| author_facet | Selorm Philip Segbefia Selorm Philip Segbefia Diana Asema Asandem Diana Asema Asandem Linda Eva Amoah Linda Eva Amoah Kwadwo Asamoah Kusi Kwadwo Asamoah Kusi |
| author_sort | Selorm Philip Segbefia |
| collection | DOAJ |
| description | Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between anti-inflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria. |
| first_indexed | 2024-03-08T04:06:29Z |
| format | Article |
| id | doaj.art-4e3e80824bf14c6fa136a092e9002f8e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T04:06:29Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4e3e80824bf14c6fa136a092e9002f8e2024-02-09T05:03:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12854111285411Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcomeSelorm Philip Segbefia0Selorm Philip Segbefia1Diana Asema Asandem2Diana Asema Asandem3Linda Eva Amoah4Linda Eva Amoah5Kwadwo Asamoah Kusi6Kwadwo Asamoah Kusi7Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, GhanaDepartment of Molecular Medicine, School of Medicine and Dentistry, College of Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaDepartment of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, GhanaCytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between anti-inflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1285411/fullcytokinesgene polymorphismsplasmodiumimmune responsepathogenesis |
| spellingShingle | Selorm Philip Segbefia Selorm Philip Segbefia Diana Asema Asandem Diana Asema Asandem Linda Eva Amoah Linda Eva Amoah Kwadwo Asamoah Kusi Kwadwo Asamoah Kusi Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome Frontiers in Immunology cytokines gene polymorphisms plasmodium immune response pathogenesis |
| title | Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome |
| title_full | Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome |
| title_fullStr | Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome |
| title_full_unstemmed | Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome |
| title_short | Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome |
| title_sort | cytokine gene polymorphisms implicated in the pathogenesis of plasmodium falciparum infection outcome |
| topic | cytokines gene polymorphisms plasmodium immune response pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1285411/full |
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