Parameter identifiability and redundancy in a general class of stochastic carcinogenesis models.

BACKGROUND: Heidenreich et al. (Risk Anal 1997 17 391-399) considered parameter identifiability in the context of the two-mutation cancer model and demonstrated that combinations of all but two of the model parameters are identifiable. We consider the problem of identifiability in the recently devel...

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Autors principals: Mark P Little, Wolfgang F Heidenreich, Guangquan Li
Format: Article
Idioma:English
Publicat: Public Library of Science (PLoS) 2009-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC2797326?pdf=render