A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder
Background: Sudden unexplained death in individuals with mental health problems was described in 1960 and a link with antipsychotic drugs was postulated over 40 years ago. Down the years, a clear relation between electrocardiography (ECG) abnormalities and antipsychotic use was observed with special...
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| Format: | Article |
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Manipal College of Medical Sciences, Pokhara
2024-04-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/61308 |
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| author | Shaswata Mandal Nitu Mallik Rudraprasad Acharya Manoj Kumar |
| author_facet | Shaswata Mandal Nitu Mallik Rudraprasad Acharya Manoj Kumar |
| author_sort | Shaswata Mandal |
| collection | DOAJ |
| description | Background: Sudden unexplained death in individuals with mental health problems was described in 1960 and a link with antipsychotic drugs was postulated over 40 years ago. Down the years, a clear relation between electrocardiography (ECG) abnormalities and antipsychotic use was observed with special emphasis on QT prolongation. Various factors modulate the risk of QT prolongation including gender, age, race, and drug choice. An evaluation of antipsychotic use-induced QT changes in Eastern Indian population is the dire need of the hour.
Aims and Objectives: The aim and objective are to study the effects of risperidone, olanzapine, and aripiprazole on QT interval after a period of 4 weeks of usage in previously drug-naïve Eastern Indian psychotic patients.
Materials and Methods: A total of 78 drug-naïve patients fulfilling inclusion and exclusion criteria were randomly assigned to receive risperidone, olanzapine, and aripiprazole after a baseline ECG. A repeat ECG after 4 weeks of drug usage was done and compared using standard protocols with respect to QT interval. Findings were tabulated and statistical analysis was done using SPSS 25.0 to test for statistical significance at P<0.05.
Results: Our study found significant rise in QT values after 4 weeks of using olanzapine and aripiprazole, but not with risperidone. However, none of the patients from either of the groups experienced any incidence of QT prolongation. Rise with olanzapine was significantly higher than that with risperidone.
Conclusion: Caution is suggested in patients with risk factors for QT prolongation or a high value of QT during prescribing olanzapine. Studies with larger sample size can be carried out to find genetic predisposition of Indian population to anti-psychotic induced QT interval rise/prolongation. |
| first_indexed | 2024-04-24T14:27:48Z |
| format | Article |
| id | doaj.art-4e41b4a1ec684597a140e3aa72e1e0ab |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-24T14:27:48Z |
| publishDate | 2024-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-4e41b4a1ec684597a140e3aa72e1e0ab2024-04-03T04:27:51ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762024-04-01154218222https://doi.org/10.3126/ajms.v15i4.61308A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorderShaswata Mandal 0https://orcid.org/0009-0007-3974-1534Nitu Mallik 1https://orcid.org/0000-0002-5346-3493Rudraprasad Acharya 2https://orcid.org/0000-0003-3638-9436Manoj Kumar3https://orcid.org/0000-0002-4781-2343Senior Resident, Program Officer, District Mental Health Program, Malda, West Bengal, India Demonstrator, Department of Psychiatry, Medical College and Hospital, Kolkata, West Bengal, India Assistant Professor, Department of Psychiatry, Diamond Harbour Government Medical College and Hospital, West Bengal, India Assistant Professor, Department of Psychiatry, ESIC Medical College and Hospital, Faridabad, Haryana, India Background: Sudden unexplained death in individuals with mental health problems was described in 1960 and a link with antipsychotic drugs was postulated over 40 years ago. Down the years, a clear relation between electrocardiography (ECG) abnormalities and antipsychotic use was observed with special emphasis on QT prolongation. Various factors modulate the risk of QT prolongation including gender, age, race, and drug choice. An evaluation of antipsychotic use-induced QT changes in Eastern Indian population is the dire need of the hour. Aims and Objectives: The aim and objective are to study the effects of risperidone, olanzapine, and aripiprazole on QT interval after a period of 4 weeks of usage in previously drug-naïve Eastern Indian psychotic patients. Materials and Methods: A total of 78 drug-naïve patients fulfilling inclusion and exclusion criteria were randomly assigned to receive risperidone, olanzapine, and aripiprazole after a baseline ECG. A repeat ECG after 4 weeks of drug usage was done and compared using standard protocols with respect to QT interval. Findings were tabulated and statistical analysis was done using SPSS 25.0 to test for statistical significance at P<0.05. Results: Our study found significant rise in QT values after 4 weeks of using olanzapine and aripiprazole, but not with risperidone. However, none of the patients from either of the groups experienced any incidence of QT prolongation. Rise with olanzapine was significantly higher than that with risperidone. Conclusion: Caution is suggested in patients with risk factors for QT prolongation or a high value of QT during prescribing olanzapine. Studies with larger sample size can be carried out to find genetic predisposition of Indian population to anti-psychotic induced QT interval rise/prolongation.https://www.nepjol.info/index.php/AJMS/article/view/61308aripiprazole; olanzapine; qt interval; risperidone |
| spellingShingle | Shaswata Mandal Nitu Mallik Rudraprasad Acharya Manoj Kumar A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder Asian Journal of Medical Sciences aripiprazole; olanzapine; qt interval; risperidone |
| title | A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder |
| title_full | A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder |
| title_fullStr | A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder |
| title_full_unstemmed | A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder |
| title_short | A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder |
| title_sort | prospective study on change of qtc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder |
| topic | aripiprazole; olanzapine; qt interval; risperidone |
| url | https://www.nepjol.info/index.php/AJMS/article/view/61308 |
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