Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan
BackgroundThe apolipoprotein E ε4 allele (APOE*ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to APOE*ε4 for depression is less clear and may be because of confounding of the relationship between dementia and depression.AimsWe examined t...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-05-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472420000290/type/journal_article |
| _version_ | 1827995682383855616 |
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| author | Richard Andrew Burns Shea Andrews Nicolas Cherbuin Kaarin Jane Anstey |
| author_facet | Richard Andrew Burns Shea Andrews Nicolas Cherbuin Kaarin Jane Anstey |
| author_sort | Richard Andrew Burns |
| collection | DOAJ |
| description | BackgroundThe apolipoprotein E ε4 allele (APOE*ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to APOE*ε4 for depression is less clear and may be because of confounding of the relationship between dementia and depression.AimsWe examined the risk of APOE* ε4 for incident depression and depressive symptomology over a 12-year period across the adult lifespan.MethodParticipants were from the Personality and Total Health Through Life study, aged 20 to 24 (n = 1420), 40 to 44 (n = 1592) or 60–64 (n = 1768) at baseline, and interviewed every 4 years since 1999. Ethnicities other than White, those without genotyping and those with depression at baseline, or who reported strokes and scores on the Mini-Mental State Examination <27 at any observation, were excluded.ResultsOver the study period, there was no evidence that APOE*ε4+ was a risk factor for depression, including any depression (odds ratio (OR) = 0.94, 95% CI 0.77–1.16, P = 0.573), major depression (OR = 0.96, 95% CI 0.60–1.53, P = 0.860), minor depression (OR = 0.94, 95% CI 0.67–1.30, P = 0.695) or depressive symptomology (incidence rate ratio (IRR) = 1.02, 95% CI 0.97–1.08, P = 0.451). APOE*ε4 was unrelated to incident depression. Findings were consistent for all age cohorts.ConclusionsAmong cognitively intact Australian adults who were free of depression at baseline, there was little evidence that APOE*ε4+ carriers are at increased risk for depression over a 12-year period among those who are cognitively intact. |
| first_indexed | 2024-04-10T05:00:10Z |
| format | Article |
| id | doaj.art-4e430f0489a84da8b287b904c481f433 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:00:10Z |
| publishDate | 2020-05-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-4e430f0489a84da8b287b904c481f4332023-03-09T12:28:58ZengCambridge University PressBJPsych Open2056-47242020-05-01610.1192/bjo.2020.29Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespanRichard Andrew Burns0https://orcid.org/0000-0002-7750-4341Shea Andrews1Nicolas Cherbuin2Kaarin Jane Anstey3Centre for Research on Ageing, Health and Wellbeing, The Australian National University, AustraliaDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, USACentre for Research on Ageing, Health and Wellbeing, The Australian National University, AustraliaSchool of Psychology, University of New South Wales, Australia; and Neuroscience Research Australia, AustraliaBackgroundThe apolipoprotein E ε4 allele (APOE*ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to APOE*ε4 for depression is less clear and may be because of confounding of the relationship between dementia and depression.AimsWe examined the risk of APOE* ε4 for incident depression and depressive symptomology over a 12-year period across the adult lifespan.MethodParticipants were from the Personality and Total Health Through Life study, aged 20 to 24 (n = 1420), 40 to 44 (n = 1592) or 60–64 (n = 1768) at baseline, and interviewed every 4 years since 1999. Ethnicities other than White, those without genotyping and those with depression at baseline, or who reported strokes and scores on the Mini-Mental State Examination <27 at any observation, were excluded.ResultsOver the study period, there was no evidence that APOE*ε4+ was a risk factor for depression, including any depression (odds ratio (OR) = 0.94, 95% CI 0.77–1.16, P = 0.573), major depression (OR = 0.96, 95% CI 0.60–1.53, P = 0.860), minor depression (OR = 0.94, 95% CI 0.67–1.30, P = 0.695) or depressive symptomology (incidence rate ratio (IRR) = 1.02, 95% CI 0.97–1.08, P = 0.451). APOE*ε4 was unrelated to incident depression. Findings were consistent for all age cohorts.ConclusionsAmong cognitively intact Australian adults who were free of depression at baseline, there was little evidence that APOE*ε4+ carriers are at increased risk for depression over a 12-year period among those who are cognitively intact.https://www.cambridge.org/core/product/identifier/S2056472420000290/type/journal_articleApolipoproteindepressioncognitive ageingdementialifespanepidemiology |
| spellingShingle | Richard Andrew Burns Shea Andrews Nicolas Cherbuin Kaarin Jane Anstey Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan BJPsych Open Apolipoprotein depression cognitive ageing dementia lifespan epidemiology |
| title | Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan |
| title_full | Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan |
| title_fullStr | Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan |
| title_full_unstemmed | Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan |
| title_short | Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan |
| title_sort | role of apolipoprotein e epsilon 4 apoe ε4 as an independent risk factor for incident depression over a 12 year period in cognitively intact adults across the lifespan |
| topic | Apolipoprotein depression cognitive ageing dementia lifespan epidemiology |
| url | https://www.cambridge.org/core/product/identifier/S2056472420000290/type/journal_article |
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