Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature
IntroductionPatients who should benefit from anti-amyloid therapies (AAT) are found across all geriatric settings. Yet, it remains unclear how the use of AAT in patients with geriatric syndromes, such as frailty and polypharmacy, has so far been discussed in the literature.MethodsArticles on aducanu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1256968/full |
| _version_ | 1797662925037502464 |
|---|---|
| author | Angélique Sadlon Angélique Sadlon Martin Ott Reto W. Kressig |
| author_facet | Angélique Sadlon Angélique Sadlon Martin Ott Reto W. Kressig |
| author_sort | Angélique Sadlon |
| collection | DOAJ |
| description | IntroductionPatients who should benefit from anti-amyloid therapies (AAT) are found across all geriatric settings. Yet, it remains unclear how the use of AAT in patients with geriatric syndromes, such as frailty and polypharmacy, has so far been discussed in the literature.MethodsArticles on aducanumab, gantenerumab, lecanemab, donanemab, crenezumab, solanezumab were retrieved in MEDLINE from inception to July 2023. For each article, identified geriatric relevant terms were assigned to five discussion contexts (eligibility of AAT study population, safety, prescription, patient clinical profile, alternative outcomes measurement). Article type and the involvement of geriatric healthcare professionals as an author were further extracted.ResultsOut of 538 articles, 23 (4.27%) were published in journals from the geriatric category, 44 (8.18%) included an author affiliated with a geriatric institution. One hundred and sixteen (21.56%) articles included at least one geriatric relevant term, which were mostly discussed in the context of safety and eligibility. Articles mentioning geriatric syndromes were more frequently authored by a geriatric healthcare professional (p = 0.044).DiscussionThe use of AAT in patients with geriatric syndromes has so far received poor attention in the literature raising concerns on their use in this patient group. The involvement of geriatric healthcare professionals in future studies may increase the relevance of AAT research in patients with geriatric syndromes. |
| first_indexed | 2024-03-11T19:07:10Z |
| format | Article |
| id | doaj.art-4e43a1831bb6412c9719e64dd9b61abf |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T19:07:10Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4e43a1831bb6412c9719e64dd9b61abf2023-10-10T06:13:11ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-10-011510.3389/fnagi.2023.12569681256968Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literatureAngélique Sadlon0Angélique Sadlon1Martin Ott2Reto W. Kressig3Department of Clinical Chemistry, Inselspital, Bern University Hospital & University of Bern, Bern, SwitzerlandAgeing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United KingdomMemory Clinic Entlisberg, Geriatric Department City of Zurich, Zurich, SwitzerlandUniversity Department of Geriatric Medicine FELIX PLATTER & University of Basel, Basel, SwitzerlandIntroductionPatients who should benefit from anti-amyloid therapies (AAT) are found across all geriatric settings. Yet, it remains unclear how the use of AAT in patients with geriatric syndromes, such as frailty and polypharmacy, has so far been discussed in the literature.MethodsArticles on aducanumab, gantenerumab, lecanemab, donanemab, crenezumab, solanezumab were retrieved in MEDLINE from inception to July 2023. For each article, identified geriatric relevant terms were assigned to five discussion contexts (eligibility of AAT study population, safety, prescription, patient clinical profile, alternative outcomes measurement). Article type and the involvement of geriatric healthcare professionals as an author were further extracted.ResultsOut of 538 articles, 23 (4.27%) were published in journals from the geriatric category, 44 (8.18%) included an author affiliated with a geriatric institution. One hundred and sixteen (21.56%) articles included at least one geriatric relevant term, which were mostly discussed in the context of safety and eligibility. Articles mentioning geriatric syndromes were more frequently authored by a geriatric healthcare professional (p = 0.044).DiscussionThe use of AAT in patients with geriatric syndromes has so far received poor attention in the literature raising concerns on their use in this patient group. The involvement of geriatric healthcare professionals in future studies may increase the relevance of AAT research in patients with geriatric syndromes.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1256968/fullanti-amyloidgeriatric syndromegeriatricAlzheimer’s diseasedisease-modifying therapiesinclusion |
| spellingShingle | Angélique Sadlon Angélique Sadlon Martin Ott Reto W. Kressig Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature Frontiers in Aging Neuroscience anti-amyloid geriatric syndrome geriatric Alzheimer’s disease disease-modifying therapies inclusion |
| title | Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature |
| title_full | Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature |
| title_fullStr | Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature |
| title_full_unstemmed | Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature |
| title_short | Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature |
| title_sort | patients with geriatric syndromes and anti amyloid therapies lack of consideration an exploratory analysis of the literature |
| topic | anti-amyloid geriatric syndrome geriatric Alzheimer’s disease disease-modifying therapies inclusion |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1256968/full |
| work_keys_str_mv | AT angeliquesadlon patientswithgeriatricsyndromesandantiamyloidtherapieslackofconsiderationanexploratoryanalysisoftheliterature AT angeliquesadlon patientswithgeriatricsyndromesandantiamyloidtherapieslackofconsiderationanexploratoryanalysisoftheliterature AT martinott patientswithgeriatricsyndromesandantiamyloidtherapieslackofconsiderationanexploratoryanalysisoftheliterature AT retowkressig patientswithgeriatricsyndromesandantiamyloidtherapieslackofconsiderationanexploratoryanalysisoftheliterature |