<i>Add Sugar to Chitosan:</i> Mucoadhesion and In Vitro Intestinal Permeability of Mannosylated Chitosan Nanocarriers

<i>Add Sugar to Chitosan:</i> Mucoadhesion and In Vitro Intestinal Permeability of Mannosylated Chitosan Nanocarriers

Crosslinked chitosan nanocarriers (140–160 nm) entrapping coumarin-6 (<i>λ<sub>ex/em</sub></i> = 455/508 nm) with or without surface mannosylation were synthesized and assessed for cytotoxicity, adherence and cellular uptake in Caco-2 cells, flux across Caco-2 monolayers, and...

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Bibliographic Details
Main Authors: Sadaf Ejaz, Bridget Hogg, Delyan R. Hristov, David J. Brayden, Muhammad Imran, Sourav Bhattacharjee
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
chitosan nanoparticles
mannosylation
surface functionalization
mucoadhesion
surface charge density
bioconjugation
Online Access:https://www.mdpi.com/1999-4923/14/4/830

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