An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring.
A wavelet multi-component decomposition algorithm has been used for data analysis of micro-Raman spectra of blood serum samples from patients affected by pemphigus vulgaris at different stages. Pemphigus is a chronic, autoimmune, blistering disease of the skin and mucous membranes with a potentially...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2008-06-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/8/6/3656/ |
| _version_ | 1818039864036163584 |
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| author | Maria Lepore Giovanni Maria Gaeta Nicola Cirillo Vito Capozzi Giuseppe Perna Flora Zenone Carlo Camerlingo |
| author_facet | Maria Lepore Giovanni Maria Gaeta Nicola Cirillo Vito Capozzi Giuseppe Perna Flora Zenone Carlo Camerlingo |
| author_sort | Maria Lepore |
| collection | DOAJ |
| description | A wavelet multi-component decomposition algorithm has been used for data analysis of micro-Raman spectra of blood serum samples from patients affected by pemphigus vulgaris at different stages. Pemphigus is a chronic, autoimmune, blistering disease of the skin and mucous membranes with a potentially fatal outcome. Spectra were measured by means of a Raman confocal microspectrometer apparatus using the 632.8 nm line of a He-Ne laser source. A discrete wavelet transform decomposition method has been applied to the recorded Raman spectra in order to overcome problems related to low-level signals and the presence of noise and background components due to light scattering and fluorescence. This numerical data treatment can automatically extract quantitative information from the Raman spectra and makes more reliable the data comparison. Even if an exhaustive investigation has not been done in this work, the feasibility of the follow-up monitoring of pemphigus vulgaris pathology has been clearly proved with useful implications for the clinical applications. |
| first_indexed | 2024-12-10T08:05:24Z |
| format | Article |
| id | doaj.art-4e497432a3224f74a7cedead8613f8a5 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-12-10T08:05:24Z |
| publishDate | 2008-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-4e497432a3224f74a7cedead8613f8a52022-12-22T01:56:42ZengMDPI AGSensors1424-82202008-06-018636563664An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring.Maria LeporeGiovanni Maria GaetaNicola CirilloVito CapozziGiuseppe PernaFlora ZenoneCarlo CamerlingoA wavelet multi-component decomposition algorithm has been used for data analysis of micro-Raman spectra of blood serum samples from patients affected by pemphigus vulgaris at different stages. Pemphigus is a chronic, autoimmune, blistering disease of the skin and mucous membranes with a potentially fatal outcome. Spectra were measured by means of a Raman confocal microspectrometer apparatus using the 632.8 nm line of a He-Ne laser source. A discrete wavelet transform decomposition method has been applied to the recorded Raman spectra in order to overcome problems related to low-level signals and the presence of noise and background components due to light scattering and fluorescence. This numerical data treatment can automatically extract quantitative information from the Raman spectra and makes more reliable the data comparison. Even if an exhaustive investigation has not been done in this work, the feasibility of the follow-up monitoring of pemphigus vulgaris pathology has been clearly proved with useful implications for the clinical applications.http://www.mdpi.com/1424-8220/8/6/3656/blood serummicro-Raman spectroscopywavelet analysis |
| spellingShingle | Maria Lepore Giovanni Maria Gaeta Nicola Cirillo Vito Capozzi Giuseppe Perna Flora Zenone Carlo Camerlingo An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring. Sensors blood serum micro-Raman spectroscopy wavelet analysis |
| title | An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring. |
| title_full | An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring. |
| title_fullStr | An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring. |
| title_full_unstemmed | An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring. |
| title_short | An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring. |
| title_sort | investigation on micro raman spectra and wavelet data analysis for pemphigus vulgaris follow up monitoring |
| topic | blood serum micro-Raman spectroscopy wavelet analysis |
| url | http://www.mdpi.com/1424-8220/8/6/3656/ |
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