Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study
PurposeTo explore the clinical value of contrast-enhanced ultrasound (CEUS) quantitative analysis in the evaluation and prognosis of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC).MethodsEighty-three consecutive patients undergoing neoadjuvant chemoradiotherapy and total mes...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1340060/full |
| _version_ | 1797348416750092288 |
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| author | Gouyang Bai Congying Wang Yi Sun Jinghua Li Xiangzhou Shi Wei Zhang Yilin Yang Ruijing Yang |
| author_facet | Gouyang Bai Congying Wang Yi Sun Jinghua Li Xiangzhou Shi Wei Zhang Yilin Yang Ruijing Yang |
| author_sort | Gouyang Bai |
| collection | DOAJ |
| description | PurposeTo explore the clinical value of contrast-enhanced ultrasound (CEUS) quantitative analysis in the evaluation and prognosis of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC).MethodsEighty-three consecutive patients undergoing neoadjuvant chemoradiotherapy and total mesorectal excision for LARC were retrospectively included. According to pathological results, patients were categorized into complete or incomplete response groups. Differences in ultrasonic parameters, pathological results, and clinical data between groups were evaluated. The cutoff point for a complete response as determined by quantitative analysis of CEUS was assessed using a receiver operating characteristic curve; additionally, overall survival (OS) and progression-free survival (PFS) were analyzed.ResultsOf the 83 patients, 12 (14.5%) achieved a complete response and 71 (85.5%) did not. There were significant between-group differences in carcinoembryonic antigen (CEA) levels, differentiation degree, proportion of tumor occupying the lumen, anterior-posterior and superior-inferior diameters of the lesion, and intensity of enhancement (P<0.05). CEUS quantitative analysis showed significant between-group differences in peak intensity (PI) and area under the curve (AUC) values (P<0.05). The OS and PFS of patients with high PI, high AUC value, and poorly differentiated cancer were significantly worse than those with low PI, low AUC values, and moderately to highly differentiated cancer (P<0.05). High CEA levels (hazard ratio: 1.02, 95% confidence interval: 1.01–1.04; P=0.002) and low differentiation (2.72, 1.12–6.62; P=0.028) were independent risk factors for PFS and OS.ConclusionsCEUS can predict the response to neoadjuvant treatment in patients with LARC. CEUS quantitative analysis is helpful for clinical prognosis. |
| first_indexed | 2024-03-08T12:04:37Z |
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| id | doaj.art-4e49a71e020e434699bf0983e9bcb8e1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T12:04:37Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4e49a71e020e434699bf0983e9bcb8e12024-01-23T09:44:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.13400601340060Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective studyGouyang Bai0Congying Wang1Yi Sun2Jinghua Li3Xiangzhou Shi4Wei Zhang5Yilin Yang6Ruijing Yang7Department of Ultrasound, Tang Du Hospital, Xi’an, ChinaDepartment of Clinical Laboratory, Tang Du Hospital, Xi’an, ChinaDepartment of Ultrasound, Tang Du Hospital, Xi’an, ChinaDepartment of Ultrasound, Tang Du Hospital, Xi’an, ChinaDepartment of Ultrasound, Tang Du Hospital, Xi’an, ChinaDepartment of Pathology, Tang Du Hospital, Xi’an, ChinaDepartment of Ultrasound, Tang Du Hospital, Xi’an, ChinaDepartment of Ultrasound, Tang Du Hospital, Xi’an, ChinaPurposeTo explore the clinical value of contrast-enhanced ultrasound (CEUS) quantitative analysis in the evaluation and prognosis of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC).MethodsEighty-three consecutive patients undergoing neoadjuvant chemoradiotherapy and total mesorectal excision for LARC were retrospectively included. According to pathological results, patients were categorized into complete or incomplete response groups. Differences in ultrasonic parameters, pathological results, and clinical data between groups were evaluated. The cutoff point for a complete response as determined by quantitative analysis of CEUS was assessed using a receiver operating characteristic curve; additionally, overall survival (OS) and progression-free survival (PFS) were analyzed.ResultsOf the 83 patients, 12 (14.5%) achieved a complete response and 71 (85.5%) did not. There were significant between-group differences in carcinoembryonic antigen (CEA) levels, differentiation degree, proportion of tumor occupying the lumen, anterior-posterior and superior-inferior diameters of the lesion, and intensity of enhancement (P<0.05). CEUS quantitative analysis showed significant between-group differences in peak intensity (PI) and area under the curve (AUC) values (P<0.05). The OS and PFS of patients with high PI, high AUC value, and poorly differentiated cancer were significantly worse than those with low PI, low AUC values, and moderately to highly differentiated cancer (P<0.05). High CEA levels (hazard ratio: 1.02, 95% confidence interval: 1.01–1.04; P=0.002) and low differentiation (2.72, 1.12–6.62; P=0.028) were independent risk factors for PFS and OS.ConclusionsCEUS can predict the response to neoadjuvant treatment in patients with LARC. CEUS quantitative analysis is helpful for clinical prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2023.1340060/fullultrasonographyneoadjuvant therapylocally advanced rectal cancerprognosiscolorectal cancer |
| spellingShingle | Gouyang Bai Congying Wang Yi Sun Jinghua Li Xiangzhou Shi Wei Zhang Yilin Yang Ruijing Yang Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study Frontiers in Oncology ultrasonography neoadjuvant therapy locally advanced rectal cancer prognosis colorectal cancer |
| title | Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study |
| title_full | Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study |
| title_fullStr | Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study |
| title_full_unstemmed | Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study |
| title_short | Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study |
| title_sort | quantitative analysis of contrast enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer a retrospective study |
| topic | ultrasonography neoadjuvant therapy locally advanced rectal cancer prognosis colorectal cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1340060/full |
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